[极早发型炎症性肠病的特征与管理]
[Features and management of very early onset inflammatory bowel disease].
作者信息
You Jie-Yu
机构信息
Department of Gastroenterology, Hunan Children′s Hospital, Changsha 410000, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2018 May;20(5):341-345. doi: 10.7499/j.issn.1008-8830.2018.05.001.
Abstract
Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease of unknown etiology. This disease includes three main types: Crohn′s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U). IBD is frequently presented in adults, but in recent years, there is a rising incidence in pediatric populations. Very early onset IBD (VEO-IBD) is a fraction of pediatric IBD, but they have exclusive phenotypic and genetic characteristics such that they are accompanied by severe disease course and resistance to conventional therapy. The purpose of this review is to provide a contemporary overview of the clinical features, pathogenesis, and management of VEO-IBD.
摘要
炎症性肠病（IBD）是一种病因不明的慢性非特异性肠道炎症性疾病。该疾病包括三种主要类型：克罗恩病（CD）、溃疡性结肠炎（UC）和未分类的IBD（IBD-U）。IBD常见于成人，但近年来，儿科人群的发病率呈上升趋势。极早发型IBD（VEO-IBD）是儿科IBD的一部分，但它们具有独特的表型和遗传特征，因此伴有严重的病程且对传统治疗耐药。本综述的目的是对VEO-IBD的临床特征、发病机制和管理提供当代概述。
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