Neill J C, Cooper S J
Department of Psychology, University of Birmingham, U.K.
Physiol Behav. 1988;44(4-5):453-9. doi: 10.1016/0031-9384(88)90305-8.
Both the real and sham intakes of a 5% sucrose solution were reduced by d-fenfluramine, quipazine (a 5-HT receptor agonist), and fluoxetine (a selective 5-HT reuptake inhibitor). These data demonstrate a serotonergic inhibitory component in the control of sham-feeding. In support of this, 8-OH-DPAT (a selective 5-HT1A agonist), which inhibits serotonergic activity at small doses via an autoreceptor mechanism, enhanced sucrose sham-feeding and reversed the suppressant effect of d-fenfluramine. Together, the results indicate a serotonergic influence on ingestional responses which is probably closely related to the oropharyngeal control of consumption.
右旋芬氟拉明、喹哌嗪（一种5-羟色胺受体激动剂）和氟西汀（一种选择性5-羟色胺再摄取抑制剂）均使5%蔗糖溶液的实际摄入量和假摄入量减少。这些数据证明了在假饲控制中存在5-羟色胺能抑制成分。支持这一点的是，8-OH-DPAT（一种选择性5-HT1A激动剂），通过自身受体机制在小剂量时抑制5-羟色胺能活性，增强了蔗糖假饲并逆转了右旋芬氟拉明的抑制作用。总之，结果表明5-羟色胺能对摄食反应有影响，这可能与口咽部的摄食控制密切相关。
