Luo Ling, Han Yang, Song Xiaojing, Zhu Ting, Zeng Yong, Li Taisheng
a Department of Infectious Diseases , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing , China.
b Department of Cardiovascular Diseases , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing , China.
HIV Clin Trials. 2018 Apr;19(2):39-45. doi: 10.1080/15284336.2018.1437863.
Objectives To determine the association of the markers of monocyte activation and arterial stiffness among HIV-infected antiretroviral therapy (ART)-naïve men. Methods Sixty HIV-infected ART-naïve men and 20 HIV-uninfected male controls without symptoms or history of cardiovascular disease were recruited. Pulse wave velocity (PWV) were used as the marker of arterial stiffness and determined using a pulse pressure analyzer. The percentage of CD16-expressing monocytes was used as a marker of monocyte activation. Plasma neopterin concentration, one of the monocyte/macrophage activation markers and plasma tissue factor (TF), the coagulation marker in response to inflammatory stimuli, were also analyzed. Multivariate analyses were used to explore the association of the percentage of CD16-expressing monocytes with arterial stiffness in HIV-infected men. Results HIV-infected ART-naïve men demonstrated significantly higher PWV (1252.8 ± 161.6 vs.1159.2 ± 108.3 cm/s, p = 0.018). The percentage of CD16-expressing monocytes was significantly higher in HIV-infected men comparing male controls (23.4 ± 6.0% vs. 19.6 ± 4.6%, p = 0.012). Plasma concentrations of neopterin (0.91 vs. 0.64 ng/ml), p < 0.001) and TF (5.29 vs. 4.43 pg/ml, p = 0.04) were higher in HIV-infected men comparing controls. In the multivariate model for PWV among HIV-infected men, the percentage of CD16-expressing monocytes (p = 0.023) and age (p = 0.017) were significantly associated with PWV. HIV viral load, CD4 count, percentage of CD8+CD38+T cells and percentage of CD8+HLA-DR+ T cells were not associated with PWV. Discussion Higher level of monocyte activation marker is associated with higher level of arterial stiffness in ART naïve HIV-infected men. HIV viral load, CD4 count, and the markers of CD8 T cell activation were unrelated to PWV.
目的 确定初治的HIV感染男性中单核细胞活化标志物与动脉僵硬度之间的关联。方法 招募60名初治的HIV感染男性和20名无症状或无心血管疾病病史的未感染HIV的男性对照。使用脉搏波速度（PWV）作为动脉僵硬度的标志物，并通过脉搏压力分析仪进行测定。表达CD16的单核细胞百分比用作单核细胞活化的标志物。还分析了血浆新蝶呤浓度（单核细胞/巨噬细胞活化标志物之一）和血浆组织因子（TF，炎症刺激反应中的凝血标志物）。采用多变量分析来探讨HIV感染男性中表达CD16的单核细胞百分比与动脉僵硬度之间的关联。结果 初治的HIV感染男性的PWV显著更高（1252.8±161.6 vs.1159.2±108.3 cm/s，p = 0.018）。与男性对照相比，HIV感染男性中表达CD16 的单核细胞百分比显著更高（23.4±6.0% vs. 19.6±4.6%，p = 0.012）。与对照相比，HIV感染男性的血浆新蝶呤浓度（0.91 vs. 0.64 ng/ml，p < 0.001）和TF（5.29 vs. 4.43 pg/ml，p = 0.04）更高。在HIV感染男性的PWV多变量模型中，表达CD16的单核细胞百分比（p = 0.023）和年龄（p = 0.017）与PWV显著相关。HIV病毒载量、CD4细胞计数、CD8+CD38+T细胞百分比和CD8+HLA-DR+T细胞百分比与PWV无关。讨论 在初治的HIV感染男性中，较高水平的单核细胞活化标志物与较高水平的动脉僵硬度相关。HIV病毒载量、CD4细胞计数和CD8 T细胞活化标志物与PWV无关。
