Mutengo Katongo H, Masenga Sepiso K, Mwesigwa Naome, Patel Kaushik P, Kirabo Annet
School of Medicine and Health Sciences, HAND Research Group, Mulungushi University, Livingstone Campus, Livingstone, Zambia.
School of Public Health and Medicine, University of Zambia, Lusaka, Zambia.
Front Cardiovasc Med. 2022 Aug 25;9:968184. doi: 10.3389/fcvm.2022.968184. eCollection 2022.
Hypertension is a risk factor for end organ damage and death and is more common in persons with HIV compared to the general population. Several mechanisms have been studied in the pathogenesis of hypertension. Current evidence suggests that the epithelial sodium channel (ENaC) plays a key role in regulating blood pressure through the transport of sodium and water across membranes in the kidney tubules, resulting in retention of sodium and water and an altered fluid balance. However, there is scarcity of information that elucidates the role of ENaC in HIV as it relates to increasing the risk for development or pathogenesis of hypertension. This review summarized the evidence to date implicating a potential role for altered ENaC activity in contributing to hypertension in patients with HIV.
高血压是终末器官损伤和死亡的危险因素，与普通人群相比，在HIV感染者中更为常见。高血压发病机制已得到了多种机制的研究。目前的证据表明，上皮钠通道（ENaC）通过在肾小管中跨膜运输钠和水来调节血压，从而导致钠和水潴留以及液体平衡改变，发挥关键作用。然而，关于ENaC在HIV中与增加高血压发生风险或发病机制相关的作用，目前的信息还很匮乏。这篇综述总结了迄今为止的证据，表明ENaC活性改变在HIV患者高血压发病中可能发挥作用。
