Tomera J F, Harakal C
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140.
Drug Nutr Interact. 1988;5(4):365-72.
Ingestion of cadmium (Cd) acetate in deionized drinking water (1 ppm) in rabbits resulted in the development of hypertension and increased left ventricular mass similar to what was observed in experimental renal hypertension (Grollman technique). Regardless of the approach, mean arterial pressures (MAP) of at least 50 mm Hg greater than those of controls developed over a 34-day period. Increased left ventricular mass relative to body weight was found in both hypertensive groups. However, only an increase in renal mass was observed in unilaterally nephrectomized animals. The increased mass of hearts and kidneys that was detected after an approximately 1-month period attests to the severity of these forms of experimental hypertension. These results demonstrate that the ingestion of drinking water contaminated with Cd can cause hypertension and an increase in left ventricular mass over a short time period in rabbits.
给家兔饮用含1 ppm醋酸镉（Cd）的去离子水，会导致其出现高血压，左心室质量增加，这与实验性肾性高血压（格罗曼技术）中观察到的情况相似。无论采用何种方法，在34天内，平均动脉压（MAP）至少比对照组高50 mmHg。两个高血压组均发现相对于体重的左心室质量增加。然而，在单侧肾切除的动物中，仅观察到肾脏质量增加。大约1个月后检测到的心脏和肾脏质量增加证明了这些形式的实验性高血压的严重性。这些结果表明，摄入受Cd污染的饮用水可在短时间内使家兔出现高血压并增加左心室质量。
