Tomera J F, Lilford K, Kukulka S P, Friend K D, Harakal C
Dept. of Anesthesiology, Harvard Medical School, Boston, MA.
Methods Find Exp Clin Pharmacol. 1994 Mar;16(2):97-107.
Heart disease still pervades all socioeconomic classes within the United States. Understanding the effects of environmentally-related pathogenesis (e.g., heavy metal accumulation) may aid in developing novel treatments for the prevention of heart dysfunction. The aim of this report was to use experimental investigation in an attempt to expand upon the multivariate importance of divalent cation interactions in the development of heart disease. Calcium and cadmium levels were measured by flame atomic absorption spectrophotometry in various tissues derived from two types of hypertensive rabbit models. Both models of hypertension developed mean arterial pressures of at least 50 mm mercury greater than those of controls over a 5 week period. Interrelationships between calcium and cadmium levels were found to exist for both hypertensive groups in the left ventricle, aorta, and renal medulla. The renal cortex showed no such interrelationship for the renal hypertensive group. Multiple interrelationships between calcium and cadmium levels and hypertrophy were also observed. These studies related the importance of endogenous or exogenous (viz, environmental) factors governing cadmium and calcium accumulation in hypertensive rabbits. The resulting relationships between divalent cations and hypertrophy were presented to draw attention to areas which remain unexplored with perspective to cardiovascular disease.
在美国，心脏病仍然普遍存在于所有社会经济阶层。了解与环境相关的发病机制（如重金属积累）的影响，可能有助于开发预防心脏功能障碍的新疗法。本报告的目的是通过实验研究，试图进一步探讨二价阳离子相互作用在心脏病发展中的多变量重要性。通过火焰原子吸收分光光度法测量了来自两种高血压兔模型的各种组织中的钙和镉水平。在5周的时间里，两种高血压模型的平均动脉压都比对照组至少高50毫米汞柱。在左心室、主动脉和肾髓质中，两个高血压组的钙和镉水平之间都存在相互关系。肾皮质在肾性高血压组中没有显示出这种相互关系。还观察到钙和镉水平与肥大之间存在多种相互关系。这些研究揭示了控制高血压兔体内镉和钙积累的内源性或外源性（即环境）因素的重要性。展示了二价阳离子与肥大之间的关系，以引起人们对心血管疾病方面仍未探索领域的关注。
