自发性高血压大鼠及易卒中型自发性高血压大鼠新生仔鼠心脏中的心钠素基因表达

Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats.

作者信息

Arai H, Nakao K, Saito Y, Sugawara A, Yamada T, Itoh H, Mukoyama M, Hosoda K, Shirakami G, Morii N

机构信息

Department of Medicine, Kyoto University School of Medicine, Japan.

出版信息

J Hypertens Suppl. 1988 Dec;6(4):S276-8. doi: 10.1097/00004872-198812040-00084.

DOI:10.1097/00004872-198812040-00084

PMID:2977162

Abstract

In order to further elucidate the expression of the atrial natriuretic factor (ANF) gene in spontaneously hypertensive rats (SHR) and the substrain, stroke-prone SHR (SHRSP), ANF messenger (m)RNA levels in the atrium and in the ventricle were measured in neonates of SHR and SHRSP and were compared with those in control Wistar-Kyoto rats (WKY). The levels of ANF mRNA in ventricles of the three strains reached approximately 7% of those in atria; however, no significant difference was observed in atrial and ventricular ANF mRNA levels among the three strains. These results demonstrate that the expression of the ANF gene in hearts from neonates of WKY, SHR and SHRSP is similar among the three strains.

摘要

为了进一步阐明心房利钠因子（ANF）基因在自发性高血压大鼠（SHR）及其亚系易卒中型SHR（SHRSP）中的表达情况，对SHR和SHRSP新生大鼠心房和心室中的ANF信使核糖核酸（mRNA）水平进行了测定，并与对照Wistar-Kyoto大鼠（WKY）进行了比较。三个品系大鼠心室中的ANF mRNA水平约为心房中的7%；然而，三个品系大鼠心房和心室的ANF mRNA水平未观察到显著差异。这些结果表明，WKY、SHR和SHRSP新生大鼠心脏中ANF基因的表达在这三个品系中相似。