Bright D R, Kisor D F, Smith A, Conaway M, Yu M
Department of Pharmaceutical Sciences, Ferris State University College of Pharmacy, 220 Ferris Dr, Big Rapids, MI 49307, USA.
Department of Pharmaceutical Sciences, Manchester University College of Pharmacy, 10627 Diebold Rd, Fort Wayne, IN 46845, USA.
Per Med. 2015 Aug;12(4):319-325. doi: 10.2217/pme.15.7.
The purpose of this study was to pilot a multisite, proof-of-concept model where community pharmacists could engage patients and physicians to provide pharmacogenetic (PGt) testing and clinical decision support.
PATIENTS & METHODS: Patients with history of acute myocardial infarction and percutaneous coronary intervention with no prior history of CYP2C19 testing.
Four community pharmacies provided pharmacogenetic testing and medication therapy management services to 30 patients, resulting in eight recommendations for antiplatelet therapy adjustment.
Pharmacists involved in the study were able to facilitate antiplatelet therapy adjustments based on PGt data regardless of baseline antiplatelet drug selection. Whereas prior literature largely revolved around PGt management in the inpatient setting, this project supports the involvement of the community pharmacist in making PGt-based recommendations.
本研究的目的是试行一种多地点的概念验证模型,使社区药剂师能够促使患者和医生接受药物遗传学(PGt)检测并提供临床决策支持。
有急性心肌梗死病史且接受过经皮冠状动脉介入治疗但之前没有CYP2C19检测史的患者。
四家社区药房为30名患者提供了药物遗传学检测和药物治疗管理服务,产生了八项抗血小板治疗调整建议。
参与该研究的药剂师能够根据PGt数据促进抗血小板治疗调整,而不论基线抗血小板药物的选择如何。尽管先前的文献主要围绕住院环境中的PGt管理,但该项目支持社区药剂师参与基于PGt提出建议。