急性心肌梗死的积极治疗
Aggressive management of acute myocardial infarction.
作者信息
Ferdinand K C
出版信息
J Natl Med Assoc. 1988 Sep;80(9):978-83.
Acute transmural myocardial infarction is usually caused by a coronary thrombus along with fixed coronary artery stenosis. Myocardial necrosis can be interrupted by the prompt use of pharmacologic and mechanical thrombolysis. Intravenous streptokinase and urokinase have been associated with approximately a 45 percent recanalization rate while the newer agent, recombinant human tissue-type plasminogen activator (rt-PA), has an average lysis rate of 70 percent intravenously. Intracoronary streptokinase and urokinase have a similar 75 percent lysis rate, but with additional costs and morbidity. Percutaneous transluminal angioplasty (PTCA) is often indicated to correct an underlying stenosis, the time of which depends on the experience and expertise of the PTCA team.
急性透壁性心肌梗死通常由冠状动脉血栓以及固定性冠状动脉狭窄引起。通过及时使用药物和机械溶栓可中断心肌坏死。静脉注射链激酶和尿激酶的再通率约为45%，而新型药物重组人组织型纤溶酶原激活剂（rt-PA）静脉注射的平均溶解率为70%。冠状动脉内注射链激酶和尿激酶的溶解率相似，为75%，但会增加费用和发病率。经皮腔内血管成形术（PTCA）常被用于纠正潜在的狭窄，其时机取决于PTCA团队的经验和专业水平。
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