Matsuno Y, Morioka S, Murakami Y, Kobayashi S, Moriyama K
Fourth Department of Internal Medicine, Shimane Medical University, Japan.
Jpn Circ J. 1988 Dec;52(12):1370-6. doi: 10.1253/jcj.52.1370.
To study myocardial contractility in hypertensive hearts with normal wall motion, we examined left ventricular end-systolic wall stress-dimension relationships (ESWDR) during a baseline period (CS: control stage) and in the eighth week after induction of systemic hypertension by Page's method (HS: hypertensive stage) in unanesthetized dogs. The mean aortic blood pressure increased from 94 +/- 11 to 142 +/- 26 mmHg (p less than 0.01). The end-diastolic left ventricular posterior wall thickness increased significantly during the HS (9.4 +/- 1.3 vs 7.3 +/- 1.3 mm; HS vs CS), and its dimension was significantly (p less than 0.05) smaller than it was during the CS (37.0 +/- 4.2 vs 39.9 +/- 4.6 mm; HS vs CS). There were no significant differences between the 2 stages in left ventricular fractional shortening (31.9 +/- 5.0 vs 32.6 +/- 2.8; HS vs CS), in end-systolic meridional left ventricular wall stress (75.3 +/- 10.8 vs 68.3 +/- 15.6 10(3) dynes/cm2; HS vs CS), or in the ESWDR slopes (98.6 +/- 17.7 vs 94.0 +/- 19.7; HS vs CS). The ESWDR dimension intercepts significantly decreased from 2.0 +/- 0.3 to 1.8 +/- 0.3 cm during the HS; that is, the relationship shifted to the left with no significant change in the slope. At autopsy, the ratio of left ventricular weight to body weight of the hypertensive dogs was significantly (p less than 0.01) greater than that of sham-operated control dogs (6.0 +/- 0.9 vs 4.3 +/- 0.5 g/kg).(ABSTRACT TRUNCATED AT 250 WORDS)
为了研究壁运动正常的高血压心脏的心肌收缩性，我们在未麻醉犬的基线期（CS：对照阶段）以及通过佩奇方法诱导全身性高血压八周后（HS：高血压阶段），检查了左心室收缩末期壁应力 - 维度关系（ESWDR）。平均主动脉血压从94±11 mmHg升高至142±26 mmHg（p＜0.01）。在HS期间，舒张末期左心室后壁厚度显著增加（9.4±1.3对7.3±1.3 mm；HS对CS），且其维度显著小于CS期间（37.0±4.2对39.9±4.6 mm；HS对CS）（p＜0.05）。在左心室缩短分数（31.9±5.0对32.6±2.8；HS对CS）、收缩末期左心室经向壁应力（75.3±10.8对68.3±15.6×10³达因/cm²；HS对CS）或ESWDR斜率（98.6±17.7对94.0±19.7；HS对CS）方面，两个阶段之间无显著差异。在HS期间，ESWDR维度截距从2.0±0.3 cm显著降至1.8±0.3 cm；也就是说，该关系向左移动，斜率无显著变化。尸检时，高血压犬的左心室重量与体重之比显著高于假手术对照犬（6.0±0.9对4.3±0.5 g/kg）（p＜0.01）。（摘要截断于250字）
