Bogomolets National Medical University, Kyiv, Ukraine.
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
Diabetes Res Clin Pract. 2018 Jul;141:190-199. doi: 10.1016/j.diabres.2018.05.005. Epub 2018 May 26.
The beneficial interaction between the microbiota and humans is how bacteria contained within the gut 'talk' to the immune system and in this landscape, probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats.
Totally, 75 rats divided into five groups were included (n = 15, in each). Rats in group I were intact. Newborn rats in groups II-V were injected with MSG. Group III (Symbiter) received 2.5 ml/kg of multiprobiotic "Symbiter" containing concentrated biomass of 14 probiotic bacteria genera. Groups IV (Symbiter-Omega) and V (Symbiter-Smectite) received a combination of probiotic biomass supplemented with flax and wheat germ oil (250 mg of each, concentration of omega-3 fatty acids 1-5%) or smectite gel (250 mg), respectively.
In all interventional groups, significant reductions of total body and visceral adipose tissue weight as compared to MSG-obesity were observed. However, the lowest prevalence of obesity was noted for Symbiter-Omega (20% vs 33.3% as compared to other interventional groups). Moreover, supplementation of probiotics with omega-3 lead to a more pronounced decrease in HOMA-IR (2.31 ± 0.13 vs 4.02 ± 0.33, p < 0.001) and elevation of adiponectin levels (5.67 ± 0.39 vs 2.61 ± 0.27, P < 0.001), compared to the obesity group.
Probiotics and nutraceuticals led to a significantly lower prevalence of obesity, reduction of insulin resistance, total and VAT weight. Our study demonstrated that supplementation of probiotics with omega-3 may have the most beneficial antiobesity properties.
肠道内的微生物与人类之间的有益相互作用是指细菌与免疫系统“交流”的方式，而在这种情况下，益生菌和营养保健品发挥着重要作用。本研究旨在确定益生菌加营养保健品（如蒙脱石或欧米伽-3）是否优于单独使用益生菌对谷氨酸单钠（MSG）诱导肥胖大鼠模型的影响。
总共纳入 75 只大鼠，分为五组（每组 15 只）。第 I 组为完整组。第 II-V 组新生大鼠注射 MSG。第 III 组（Symbiter）接受 2.5ml/kg 的多益生菌“Symbiter”，其中含有 14 种益生菌属的浓缩生物量。第 IV 组（Symbiter-Omega）和第 V 组（Symbiter-Smectite）分别接受益生菌生物量补充亚麻籽和小麦胚芽油（各 250mg，ω-3 脂肪酸浓度 1-5%）或蒙脱石凝胶（250mg）的组合。
在所有干预组中，与 MSG 肥胖相比，全身和内脏脂肪组织重量均显著降低。然而，Symbiter-Omega 组的肥胖发生率最低（20%，与其他干预组相比为 33.3%）。此外，与肥胖组相比，益生菌加欧米伽-3 的补充导致 HOMA-IR 显著降低（2.31±0.13 与 4.02±0.33，p<0.001）和脂联素水平升高（5.67±0.39 与 2.61±0.27，P<0.001）。
益生菌和营养保健品可显著降低肥胖发生率，降低胰岛素抵抗、总脂肪和 VAT 重量。我们的研究表明，益生菌加欧米伽-3 的补充可能具有最有益的抗肥胖特性。
