Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Curr Opin Immunol. 2018 Aug;53:137-142. doi: 10.1016/j.coi.2018.04.028. Epub 2018 May 14.
The liver is the largest lymph producing organ. A significant increase in the number of hepatic lymphatic vessels, or lymphangiogenesis, has been reported in various liver diseases, including, but not limited to, cirrhosis, viral hepatitis and hepatocellular carcinoma. Despite its apparent relevance in healthy and diseased livers as these and other observations indicate, the hepatic lymphatic system has been poorly studied. With knowledge of the lymphatic system in other organs and tissues incorporated, this review article addresses the current knowledge of the hepatic lymphatic system and the potential role of lymphatic endothelial cells in the health and the disease of the liver and concludes with a brief description on future directions of the study of the hepatic lymphatic system.
肝脏是最大的淋巴生成器官。已有报道称，在各种肝脏疾病中，包括但不限于肝硬化、病毒性肝炎和肝细胞癌，肝内淋巴管数量显著增加，即淋巴管生成。尽管如这些观察结果所表明的，它在健康和患病肝脏中具有明显的相关性，但肝内淋巴系统的研究还很不完善。本文结合其他器官和组织的淋巴系统知识，阐述了肝内淋巴系统的现有知识，以及淋巴内皮细胞在肝脏健康和疾病中的潜在作用，并简要描述了肝内淋巴系统研究的未来方向。
