Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695-7617, USA.
Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695-7617, USA.
Curr Opin Pharmacol. 2018 Aug;41:66-73. doi: 10.1016/j.coph.2018.05.001. Epub 2018 May 14.
The physiological actions of estrogens are primarily mediated by the nuclear hormone receptors estrogen receptor alpha (ERα) and beta (ERβ). Activities of these nuclear steroid hormone receptors in etiology and progression of many hormone-responsive cancers are well-established, yet the specific role of each receptor, and their various expressed isoforms, in estrogen-responsive cancers remains unclear. Recent advances in nuclear receptor profiling, characterization of expressed splice variants, and the availability of new experimental cancer models, has extended the understanding of the complex interplay between the differentially expressed nuclear estrogen receptors. In this review, we discuss proposed roles of ERβ in several subtypes of cancers that lack significant ERα expression and define current understanding of how different ERs collaborate to regulate cellular processes.
雌激素的生理作用主要通过核激素受体雌激素受体α（ERα）和β（ERβ）来介导。这些核甾体激素受体在许多激素反应性癌症的病因和进展中的作用已得到充分证实，然而，每个受体及其各种表达的异构体在雌激素反应性癌症中的具体作用仍不清楚。核受体分析、表达剪接变体的特征以及新的实验性癌症模型的出现，这些新进展扩展了对不同表达的核雌激素受体之间复杂相互作用的理解。在这篇综述中，我们讨论了 ERβ 在缺乏显著 ERα 表达的几种癌症亚型中的作用，并定义了当前对不同 ER 如何协同调节细胞过程的理解。
