Department of Urology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan Province, China.
Department of Urology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan Province, China.
Biomed Pharmacother. 2018 Aug;104:119-126. doi: 10.1016/j.biopha.2018.05.029. Epub 2018 May 15.
V-ets erythroblastosis virus E26 oncogene homolog 2 (ETS2), belonging to the ETS family of transcription factors, is implicated in a broad range of cellular functions. Recently, ETS2 has been found playing an important role in the progression of some types of cancers. However, it remains unclear whether ETS2 has any effects on renal cell carcinoma (RCC). In this study, we investigated the biological functions of ETS2 in RCC. The results showed that ETS2 was highly expressed in RCC tissues and cell lines and its expression had an association with clinicopathological characteristics of RCC patients. In addition, down-regulation of ETS2 significantly inhibited RCC cell invasion in vitro and metastasis in vivo as well as suppressed the epithelial-mesenchymal transition (EMT) process. We also found that ETS2 down-regulation significantly reduced the levels of PI3K and Akt phosphorylation in RCC cells. Taken together, we suggest that ETS2 is of potential value as a molecular target for RCC treatment.
V-ets 红细胞白血病病毒 E26 癌基因同源物 2（ETS2）属于转录因子 ETS 家族，涉及广泛的细胞功能。最近发现 ETS2 在某些类型癌症的进展中起着重要作用。然而，ETS2 是否对肾细胞癌（RCC）有任何影响尚不清楚。在这项研究中，我们研究了 ETS2 在 RCC 中的生物学功能。结果表明，ETS2 在 RCC 组织和细胞系中高表达，其表达与 RCC 患者的临床病理特征有关。此外，下调 ETS2 显著抑制 RCC 细胞体外侵袭和体内转移，并抑制上皮-间充质转化（EMT）过程。我们还发现，下调 ETS2 显著降低了 RCC 细胞中 PI3K 和 Akt 磷酸化水平。综上所述，我们认为 ETS2 作为 RCC 治疗的潜在分子靶点具有一定的价值。
