Priority Area Asthma & Allergy, Research Center Borstel, 23845 Borstel, Germany, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL),
Department of Rheumatology, University of Lubeck, 23538, Lubeck, Germany.
Front Biosci (Landmark Ed). 2018 Jun 1;23(11):2053-2064. doi: 10.2741/4689.
Muscarinic acetylcholine receptor M (M3R) is a GPCR on exocrine gland cells involved in fluid secretion. In the last two decades, evidence has been accumulated arguing for a role of autoantibodies (aab) against M3R in the development of Sjögren's syndrome (SS). In this review, we provide an updated overview on this issue and critically discuss the relation between autoimmunity to M3R and SS pathogenesis. Clinical data as well as findings from experimental disease were summarized in categories addressing the presence of aab against M3R in SS patients, the function of anti-M3R aab, the association of aab against M3R with SS-related phenotypes, pathogenicity of transferred aab against M3R in mice, and mouse models induced via immunization with M3R. Based on these comprehensive data, we propose a hypothetic model for the role of aab against M3R in the pathogenesis of SS.
毒蕈碱型乙酰胆碱受体 M（M3R）是一种位于外分泌腺细胞上的 G 蛋白偶联受体，参与液体分泌。在过去的二十年中，有证据表明针对 M3R 的自身抗体（aab）在干燥综合征（SS）的发病机制中起作用。在这篇综述中，我们提供了对此问题的最新概述，并批判性地讨论了针对 M3R 的自身免疫与 SS 发病机制之间的关系。临床数据和实验疾病的结果根据以下类别进行了总结：SS 患者中针对 M3R 的 aab 的存在、抗-M3R aab 的功能、针对 M3R 的 aab 与 SS 相关表型的关联、针对 M3R 的转移 aab 在小鼠中的致病性，以及通过用 M3R 免疫诱导的小鼠模型。基于这些综合数据，我们提出了一个针对针对 M3R 的 aab 在 SS 发病机制中作用的假设模型。
