Department of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark.
Biomolecules. 2018 May 16;8(2):27. doi: 10.3390/biom8020027.
Bacterial biofilms pose a major threat to public health, as they are associated with at least two thirds of all infections. They are highly resilient and render conventional antibiotics inefficient. As a part of the innate immune system, antimicrobial peptides have drawn attention within the last decades, as some of them are able to eradicate biofilms at sub-minimum inhibitory concentration (MIC) levels. However, peptides possess a number of disadvantages, such as susceptibility to proteolytic degradation, pH and/or salinity-dependent activity and loss of activity due to binding to serum proteins. Hence, proteolytically stable peptidomimetics were designed to overcome these drawbacks. This paper summarizes the current peptide and peptidomimetic strategies for combating bacteria-associated biofilm infections, both in respect to soluble and surface-functionalized solutions.
细菌生物膜对公共健康构成重大威胁，因为它们与至少三分之二的感染有关。它们具有高度的弹性，使传统抗生素无效。作为先天免疫系统的一部分，抗菌肽在过去几十年中引起了人们的关注，因为其中一些肽能够在亚最小抑制浓度 (MIC) 水平下消灭生物膜。然而，肽类具有许多缺点，例如易受蛋白水解降解、pH 值和/或盐度依赖性活性以及由于与血清蛋白结合而导致的活性丧失。因此，设计了蛋白水解稳定的肽模拟物来克服这些缺点。本文总结了目前用于对抗与细菌相关的生物膜感染的肽和肽模拟物策略，包括可溶性和表面功能化溶液。
