Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, n.2752, CEP 90610-000, Bairro Azenha, Porto Alegre, Rio Grande do Sul, Brazil.
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, n.2752, CEP 90610-000, Bairro Azenha, Porto Alegre, Rio Grande do Sul, Brazil.
Eur J Pharm Sci. 2018 Mar 1;114:114-137. doi: 10.1016/j.ejps.2017.11.008. Epub 2017 Nov 11.
Biofilm forming microorganisms substantially enhance their virulence and drug resistance causing and alternatives are need to combat this health problem. In this context, peptides are an exceptional strategy in drug design and pharmaceutical innovation due to their diverse chemical features, biological activity and biotechnological relevance. Therefore, this study proposes a comprehensive assessment of a wide range of peptides, targeting biofilms. It provides chemical and molecular information and a Structural Activity Relationship perspective in order to delineate minimal requirements for antibiofilm activity and contributing to the development of new antibiofilm agents. In light of this, it was possible to propose a peptide design model (X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X) to be tested in the war against resistant microorganisms.
生物膜形成微生物极大地增强了它们的毒力和耐药性，因此需要寻找替代方法来应对这一健康问题。在这种情况下，由于其多样化的化学特征、生物活性和生物技术相关性，肽类是药物设计和药物创新的一种特殊策略。因此，本研究针对生物膜提出了对广泛肽类的综合评估。它提供了化学和分子信息以及结构活性关系的视角，以便描绘出抗生物膜活性的最小要求，并有助于开发新的抗生物膜药物。有鉴于此，有可能提出一个肽设计模型 (X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X-X) 来对抗耐药微生物。
