分析人体膝关节某些部位的铬含量。
Analysis of the Content of Chromium in Certain Parts of the Human Knee Joint.
机构信息
The Jan Grodek Higher Vocational State School, Medical Institute, 21 Mickiewicza Str., 38-500 Sanok, Poland.
Department of Toxicology and Bioanalysis, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, 4 Jagiellonska Str., 41-200 Sosnowiec, Poland.
出版信息
Int J Environ Res Public Health. 2018 May 17;15(5):1013. doi: 10.3390/ijerph15051013.
Chromium is an essential microelement in the human body. It exerts an effect on bones by modulating their biochemical parameters: alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP). With considerable accumulation of chromium in the skeleton, the activity of alkaline phosphatase was found to decrease, which affected bone formation rate. The study objective was to analyze chromium content in the knee tissues. Tissues for analysis were obtained during endoprosthesoplasty of the knee joint and included tibia, femur, and meniscus tissues. Samples were collected from 50 patients, including 36 women and 14 men. The analysis was performed using the inductively coupled plasma atomic emission spectroscopy (ICP-AES) method, by means of a Varian 710-ES apparatus. The results revealed no significant differences in the content of chromium in the knee joint tissues between women and men. The highest level of chromium was found in the femoral bone of the knee joint, then in the meniscus, and was lowest in the tibia, although the differences were statistically insignificant. Chromium content increased with age.
铬是人体必需的微量元素。它通过调节骨骼的生化参数——碱性磷酸酶（ALP）和抗酒石酸酸性磷酸酶（TRAP）——对骨骼发挥作用。随着铬在骨骼中大量积累，碱性磷酸酶的活性被发现降低，这影响了骨形成率。本研究旨在分析膝关节组织中的铬含量。分析用的组织取自膝关节的人工关节置换术，包括胫骨、股骨和半月板组织。从 50 名患者中采集样本，其中包括 36 名女性和 14 名男性。采用电感耦合等离子体原子发射光谱法（ICP-AES），使用 Varian 710-ES 仪器进行分析。结果显示，女性和男性膝关节组织中的铬含量无显著差异。膝关节中铬含量最高的是股骨，然后是半月板，胫骨中含量最低，但差异无统计学意义。铬含量随年龄增长而增加。
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