Manno C, Stella M, Manno M, Fornarelli G, D'Agostino C, Quagliara D, Schena F P
S. Rita Nephrology and Dialysis Center, Bari, Italy.
Clin Nephrol. 1988 Dec;30(6):308-14.
The plasma concentration of the immunoreactive (IR) human atrial natriuretic factor (hANF) was measured in 17 patients with primary IgA nephropathy (IgAN) (9 normotensive and 8 hypertensive subjects without impairment of renal function). Furthermore, correlations with the renin-angiotensin II-aldosterone system and hemodynamic alterations were studied. The mean value of IR-hANF was significantly (p less than 0.002) higher in normotensive IgAN patients (68.2 +/- 14.6 pg/ml) than in controls (48.8 +/- 11.5 pg/ml), while it was slightly and not significantly elevated in hypertensive IgAN patients (58.5 +/- 8.4 pg/ml). In the latter the mean plasma renin activity (PRA) was significantly increased (0.92 +/- 0.30 ng/ml/h; p less than 0.002), while in normotensive IgAN patients (0.68 +/- 0.58 ng/ml/h) no difference was observed. Plasma aldosterone levels showed the same behavior pattern as those of PRA. Hemodynamic studies showed that the mean values of the cardiac index (CI) were significantly (p less than 0.002) high in both normotensive (3.55 +/- 0.5 l/min/m2) and hypertensive (3.32 +/- 0.47 l/min/m2) patients, while a significant reduction in the total peripheral resistance index (TPRI) in normotensive (2171 +/- 349 dyn/s/cm-5/m2; p less than 0.02) and a significant increase in hypertensive (2959 +/- 440 dyn/s/cm-5/m2; p less than 0.05) patients were observed. The mean arterial pressure (MAP) had a positive correlation with the TPRI and an inverse correlation with the IR-hANF.(ABSTRACT TRUNCATED AT 250 WORDS)
对17例原发性IgA肾病（IgAN）患者（9例血压正常且8例血压升高但肾功能未受损）测定了免疫反应性（IR）人心房利钠因子（hANF）的血浆浓度。此外，研究了其与肾素 - 血管紧张素II - 醛固酮系统及血流动力学改变的相关性。血压正常的IgAN患者中IR - hANF的平均值（68.2±14.6 pg/ml）显著高于对照组（48.8±11.5 pg/ml，p<0.002），而血压升高的IgAN患者中其升高幅度较小且无统计学意义（58.5±8.4 pg/ml）。在后者中，平均血浆肾素活性（PRA）显著升高（0.92±0.30 ng/ml/h；p<0.002），而血压正常的IgAN患者（0.68±0.58 ng/ml/h）未观察到差异。血浆醛固酮水平表现出与PRA相同的行为模式。血流动力学研究表明，血压正常（3.55±0.5 l/min/m²）和血压升高（3.32±0.47 l/min/m²）患者的心脏指数（CI）平均值均显著升高（p<0.002），而血压正常患者的总外周阻力指数（TPRI）显著降低（2171±349 dyn/s/cm⁻⁵/m²；p<0.02），血压升高患者的TPRI显著升高（2959±440 dyn/s/cm⁻⁵/m²；p<0.05）。平均动脉压（MAP）与TPRI呈正相关，与IR - hANF呈负相关。（摘要截选至250字）
