Iseki K, Onoyama K, Fujimi S, Omae T
Clin Nephrol. 1981 Sep;16(3):137-41.
The acute effects of 50 mg of SQ 14225 (Captopril) on arterial pressure, cardiac output, total peripheral resistance (TPR) and plasma renin activity (PRA) were studied in 14 chronic hemodialysis patients, six of whom were hypertensive. Before treatment, TPR index (TPRI) correlated significantly with mean arterial pressure (MAP) (r = 0.806, P less than 0.01). After Captopril, the reduction of MAP was 10% or more in hypertensive and normotensive subjects at 30 and 120 min. The percentage change in MAP correlated significantly with that in TPRI in all the patients at 30 (r = 0.872, P less than 0.01) and 120 min (r = 0.866, P less than 0.01). There was no correlation between either the changes in cardiac index or the basal values of PRA and the decrease in MAP. The result suggests that vasodilatation was primarily responsible for the fall in blood pressure in chronic hemodialysis patients.
在14例慢性血液透析患者中研究了50毫克SQ 14225（卡托普利）对动脉压、心输出量、总外周阻力（TPR）和血浆肾素活性（PRA）的急性影响，其中6例为高血压患者。治疗前，TPR指数（TPRI）与平均动脉压（MAP）显著相关（r = 0.806，P < 0.01）。服用卡托普利后，高血压和血压正常的受试者在30分钟和120分钟时MAP降低10%或更多。在所有患者中，30分钟时（r = 0.872，P < 0.01）和120分钟时（r = 0.866，P < 0.01）MAP的变化百分比与TPRI的变化百分比显著相关。心脏指数的变化或PRA的基础值与MAP的降低之间均无相关性。结果表明，血管舒张是慢性血液透析患者血压下降的主要原因。
