心钠素对人乳内动脉的血管舒张作用。

Vasorelaxant effects of atriopeptins in human internal mammary artery.

作者信息

McMahon E G, Marshall W G

机构信息

G.D. Searle Research and Development, Washington University School of Medicine, Department of Pharmacology, St. Louis, MO 63110.

出版信息

Eur J Pharmacol. 1988 Oct 11;155(1-2):155-8. doi: 10.1016/0014-2999(88)90414-1.

DOI:10.1016/0014-2999(88)90414-1

PMID:2977336

Abstract

The vasorelaxant effects of the atriopeptins, AP-(103-126) and AP-(103-123) were compared in human internal mammary artery (IMA) rings which had been contracted with norepinephrine. AP-(103-126) completely relaxed the IMA with an IC50 within the physiologically relevant range (15 nM). However, relaxation with AP-(103-123) was greatly reduced compared to AP-(103-126), with complete relaxation observed in only half of the vessels tested and only at concentrations of 10-50 microM. These results indicate that the atriopeptin (AP) receptor in human arteries may be more similar to the AP receptor in rabbit rather than rat arteries.

摘要

比较了心房肽AP-(103 - 126)和AP-(103 - 123)对已用去甲肾上腺素收缩的人乳内动脉(IMA)环的血管舒张作用。AP-(103 - 126)能使IMA完全舒张，其IC50在生理相关范围内(15 nM)。然而，与AP-(103 - 126)相比，AP-(103 - 123)的舒张作用大大降低，仅在一半的受试血管中观察到完全舒张，且仅在浓度为10 - 50 microM时出现。这些结果表明，人动脉中的心房肽(AP)受体可能更类似于兔而非大鼠动脉中的AP受体。