Rapoport R M, Ginsburg R, Waldman S A, Murad F
Eur J Pharmacol. 1986 May 13;124(1-2):193-6. doi: 10.1016/0014-2999(86)90144-5.
The effects of atriopeptins on relaxation and cyclic GMP levels were examined in human coronary artery. alpha-Atrial natriuretic polypeptide and atriopeptins I, II and III all induced relaxation. Relaxations to atriopeptin I were of a smaller magnitude. The atriopeptins elevated cyclic GMP levels from 2- to 3-fold. These studies suggest that atriopeptins released from the heart may dilate the vasculature of this organ and increase coronary blood flow through the formation of cyclic GMP.
在人冠状动脉中研究了心房肽对舒张和环磷酸鸟苷（cGMP）水平的影响。α-心房利钠多肽及心房肽I、II和III均能诱导舒张。对心房肽I的舒张作用幅度较小。心房肽可使环磷酸鸟苷水平升高2至3倍。这些研究表明，心脏释放的心房肽可能会扩张该器官的血管，并通过环磷酸鸟苷的形成增加冠状动脉血流量。
