Lodi M, Cavallini G, Susa A, Lanfredi M
Istituto di Patologia Generale, Università degli Studi di Ferrara, Facoltà di Medicina e Chirurgia, Italy.
Int Angiol. 1988 Oct-Dec;7(4):344-8.
Thirty-eight patients affected by peripheral vascular insufficiency, and twelve healthy volunteers, were submitted to a cellular immunity test: LAI test, in which leukocytes fail to adhere to glass in contact with a sensitizing antigen. Patients were divided as follows: Class 1: Dacron+PTFE grafted patients, Class 2: Dacron, Class 3: PTFE, Class 4: controls. Total leukocytes, mononuclear cells, T and B lymphocytes were used as cellular populations. Finely minced Dacron and PTFE fabric vascular prostheses were employed as targets. This research showed that a T cellular immune-reactivity towards Dacron and PTFE respectively occurs in Dacron and PTFE grafted patients, and that reactivity is greater in case of Dacron. Wider researches are required to state the immune system role in fabric prostheses patency; at this regard, must be kept in mind that T lymphocytes release thrombogenic factors in course of cellular immune response.
38例外周血管功能不全患者和12名健康志愿者接受了一项细胞免疫测试：淋巴细胞转化试验（LAI试验），即在接触致敏抗原时白细胞无法黏附于玻璃。患者分为以下几类：1类：植入涤纶和聚四氟乙烯移植物的患者；2类：植入涤纶移植物的患者；3类：植入聚四氟乙烯移植物的患者；4类：对照组。使用全白细胞、单核细胞、T淋巴细胞和B淋巴细胞作为细胞群体。将精细切碎的涤纶和聚四氟乙烯织物血管假体用作靶标。这项研究表明，植入涤纶和聚四氟乙烯移植物的患者分别对涤纶和聚四氟乙烯产生T细胞免疫反应，并且涤纶移植物患者的反应更强。需要进行更广泛的研究来阐明免疫系统在织物假体通畅性中的作用；在这方面，必须牢记T淋巴细胞在细胞免疫反应过程中会释放促血栓形成因子。
