Warner Wayne A, Lee Tammy Y, Fang Fang, Llanos Adana A M, Bajracharya Smriti, Sundaram Vasavi, Badal Kimberly, Sookdeo Vandana Devika, Roach Veronica, Lamont-Greene Marjorie, Ragin Camille, Slovacek Simeon, Ramsoobhag Krishan, Brown Jasmine, Rebbeck Timothy R, Maharaj Ravi, Drake Bettina F
Oncology Division, Siteman Cancer Center, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
MedSeq HealthCare Solutions, Trincity, Trinidad and Tobago.
Cancer Causes Control. 2018 Jul;29(7):685-697. doi: 10.1007/s10552-018-1038-8. Epub 2018 May 17.
In Trinidad and Tobago (TT), prostate cancer (CaP) is the most commonly diagnosed malignancy and the leading cause of cancer deaths among men. TT currently has one of the highest CaP mortality rates in the world.
6,064 incident and 3,704 mortality cases of CaP occurring in TT from January 1995 to 31 December 2009 reported to the Dr. Elizabeth Quamina Cancer population-based cancer registry for TT, were analyzed to examine CaP survival, incidence, and mortality rates and trends by ancestry and geography.
The age-standardized CaP incidence and mortality rates (per 100,000) based on the 1960 world-standardized in 2009 were 64.2 and 47.1 per 100,000. The mortality rate in TT increased between 1995 (37.9 per 100,000) and 2009 (79.4 per 100,000), while the rate in the US decreased from 37.3 per 100,000 to 22.1 per 100,000 over the same period. Fewer African ancestry patients received treatment relative to those of Indian and mixed ancestry (45.7%, 60.3%, and 60.9%, respectively).
Notwithstanding the limitations surrounding data quality, our findings highlight the increasing burden of CaP in TT and the need for improved surveillance and standard of care. Our findings highlight the need for optimized models to project cancer rates in developing countries like TT. This study also provides the rationale for targeted screening and optimized treatment for CaP to ameliorate the rates we report.
在特立尼达和多巴哥（TT），前列腺癌（CaP）是最常被诊断出的恶性肿瘤，也是男性癌症死亡的主要原因。TT目前是世界上CaP死亡率最高的地区之一。
分析了1995年1月1日至2009年12月31日期间向TT的伊丽莎白·夸米纳博士基于人群的癌症登记处报告的TT发生的6064例CaP发病病例和3704例死亡病例，以按血统和地理位置检查CaP生存率、发病率、死亡率及趋势。
基于2009年1960年世界标准化的年龄标准化CaP发病率和死亡率（每10万人）分别为64.2和47.1。TT的死亡率在1995年（每10万人37.9）至2009年（每10万人79.4）期间有所上升，而同期美国的死亡率从每10万人37.3降至22.1。与印度血统和混合血统患者相比，非洲血统患者接受治疗的人数较少（分别为45.7%、60.3%和60.9%）。
尽管数据质量存在局限性，但我们的研究结果突出了TT中CaP负担日益加重的情况以及改善监测和护理标准的必要性。我们的研究结果强调了需要优化模型来预测像TT这样的发展中国家的癌症发病率。本研究还为CaP的靶向筛查和优化治疗提供了理论依据，以改善我们报告的发病率。
