Zhao Xiang, Nguyen Edward T, Hong Anh N, Feng Pingyun, Bu Xianhui
Department of Chemistry and Biochemistry, California State University Long Beach, 1250 Bellflower Boulevard, Long Beach, CA, 90840, USA.
Department of Chemistry, University of California, Riverside, CA, 92521, USA.
Angew Chem Int Ed Engl. 2018 Jun 11;57(24):7101-7105. doi: 10.1002/anie.201802911. Epub 2018 May 17.
Homochiral metal-organic frameworks (MOFs) are an important class of chiral solids with potential applications in chiral recognition; however, relatively few are available. Of great importance is the availability of low-cost, racemization-resistant, and versatile enantiopure building blocks. Among chiral building blocks, d-camphoric acid is highly prolific, yet, its trans-isomer, l-isocamphoric acid, has remained unknown in the entire field of solid-state materials. Its rich yet totally untapped synthetic and structural chemistry has now been investigated through the synthesis of a large family of homochiral metal isocamphorates. The first observation of diastereoisomerism in isostructural MOFs is presented. Isocamphorate has a powerful ability to create framework topologies unexpected from common inorganic building blocks, and isocamphoric acid should allow access to hundreds of new homochiral materials.
同手性金属有机框架（MOF）是一类重要的手性固体，在手性识别方面具有潜在应用；然而，现有的此类材料相对较少。低成本、抗消旋且通用的对映体纯构筑单元的可得性至关重要。在手性构筑单元中，d-樟脑酸应用广泛，但其反式异构体l-异樟脑酸在整个固态材料领域仍无人知晓。现在，通过合成一大类同手性异樟脑酸金属盐，对其丰富但完全未被开发的合成化学和结构化学进行了研究。本文首次报道了同构MOF中的非对映异构现象。异樟脑酸根具有强大的能力，能够创造出常见无机构筑单元所无法预期的框架拓扑结构，而异樟脑酸应能带来数百种新型同手性材料。
