Department of Dermatology, Venereology and Leprology, Government Medical College and Hospital, Chandigarh, India.
Department of Biochemistry, Government Medical College and Hospital, Chandigarh, India.
J Cosmet Dermatol. 2019 Feb;18(1):401-407. doi: 10.1111/jocd.12559. Epub 2018 May 17.
Diffuse hair loss (DHL) is a common problem in adult women and has a major impact on quality of life. Ascertaining the etiological diagnosis is a challenging task in such patients. Satisfactory treatment can only be instituted after ascertaining the cause of hair loss.
To study the clinico-epidemiological profile of nonscarring DHL in females and to ascertain its underlying etiological factors.
Of a total of 110 females, who presented with nonscarring DHL to the outpatient dermatology department, 100 qualified for inclusion in the study. A detailed history, clinical examination, and laboratory investigations were performed in all the patients. Statistical analysis was performed on the data collected.
Of 100 cases of DHL which were included in the study, commonest was chronic telogen effluvium (CTE) (62%), followed by female pattern hair loss (FPHL) (22%) and acute telogen effluvium (ATE) (16%). Incidence of hair loss was highest in 21-40 years age group. Psychological stress was seen to be a precipitating factor in 18 patients and found most commonly in women belong to CTE group (n-16, 25.8%). Hemoglobin levels ranged from 80 to 142 gm/L (mean: 119 ± 110). Low hemoglobin level (<120 gm/L) was observed in 57% patients. Total serum ferritin <10 ng/mL was seen in 20 patients, vitamin B12 < 211 pg/mL in 76 cases, vitamin D3 < 30 ng/mL in 81 cases. Subclinical hypothyroidism was present in 11% cases.
Nonscarring DHL is a multifactorial condition with highest incidence in 21- to 40-year age group. Serum ferritin, serum vitamin B12, and D3 levels seem to have a contributing role in the pathogenesis of hair loss, and their supplementation may be needed for a faster regrowth of hair in all cases of hair loss irrespective of the pattern.
弥漫性脱发（DHL）是成年女性常见的问题，对生活质量有重大影响。确定病因诊断对这些患者来说是一项具有挑战性的任务。只有确定脱发的原因，才能进行满意的治疗。
研究女性非瘢痕性弥漫性脱发的临床流行病学特征，并确定其潜在的病因因素。
在皮肤科门诊就诊的 110 名非瘢痕性弥漫性脱发女性中，共有 100 名符合纳入研究标准。对所有患者进行详细的病史询问、临床检查和实验室检查。对收集的数据进行统计分析。
在纳入研究的 100 例 DHL 中，最常见的是慢性休止期脱发（CTE）（62%），其次是女性型脱发（FPHL）（22%）和急性休止期脱发（ATE）（16%）。脱发发病率最高的年龄段为 21-40 岁。心理压力被认为是 18 例患者的诱发因素，最常见于 CTE 组的女性（n=16，25.8%）。血红蛋白水平为 80-142 g/L（均值：119±110）。57%的患者血红蛋白水平<120 g/L。20 例患者总血清铁蛋白<10 ng/mL，76 例患者维生素 B12<211 pg/mL，81 例患者维生素 D3<30 ng/mL。亚临床甲状腺功能减退症见于 11%的病例。
非瘢痕性弥漫性脱发是一种多因素疾病，高发年龄为 21-40 岁。血清铁蛋白、血清维生素 B12 和 D3 水平似乎在脱发发病机制中起作用，所有脱发患者，无论脱发模式如何，补充这些物质可能有助于更快地毛发生长。
