Poonia Kavita, Bhalla Mala
Department of Dermatology, Venereology and Leprology, All India Institute of Medical Science, Bathinda, Punjab, India.
Department of Dermatology, Venereology and Leprology, Government Medical College and Hospital, Chandigarh, India.
Indian Dermatol Online J. 2024 Aug 30;15(5):721-731. doi: 10.4103/idoj.idoj_807_23. eCollection 2024 Sep-Oct.
Hair symbolizes well-being and self-expression, with graying occurring naturally among different racial groups at varying ages. Premature graying has psychological and societal impacts, influencing self-esteem and quality of life. Gray hair usually advances gradually and is permanent, with occasional reports of natural repigmentation. Premature graying of hair (PMGH) results from a complex interplay of genetic, environmental, and cellular factors.
Studies exploring links between gray hair and conditions such as osteopenia, hearing loss, smoking, obesity, dyslipidemia, and cardiovascular disease have yielded mixed results. Despite continuous research into the causes of gray hair, effective, evidence-based treatments are lacking and still need to be improved.
Herein, we reviewed the causes, mechanisms, risk factors, psychosocial effects, and emerging therapies for PMGH.
头发象征着健康和自我表达，不同种族群体在不同年龄自然出现白发。过早白发具有心理和社会影响，会影响自尊和生活质量。白发通常逐渐出现且不可逆转，偶尔有自然恢复色素沉着的报道。过早白发（PMGH）是由遗传、环境和细胞因素的复杂相互作用导致的。
探索白发与骨质减少、听力损失、吸烟、肥胖、血脂异常和心血管疾病等状况之间联系的研究结果不一。尽管对白发原因的研究不断，但缺乏有效的循证治疗方法，仍有待改进。
在此，我们综述了过早白发的原因、机制、危险因素、心理社会影响及新兴疗法。
