Xie Wenjian, Yin Qian, Zhang Mengran, Li Shengnan, Chen Shaoliang
Department of Cardiology, Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing 210006.
General Clinical Research Center, Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing 210006.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Apr 28;43(4):421-427. doi: 10.11817/j.issn.1672-7347.2018.04.014.
To investigate the potential correlation between miR-223 level in leukocytes and platelet responses to clopidogrel in patients with coronary artery disease. Methods: A cohort of 188 outpatients, who conducted percutaneous coronary intervention (PCI) and received dual antiplatelet therapy, were recruited. The patient's electronic health data were collected, and their blood samples were obtained for measurement of adenosine diphosphate (ADP)-induced whole-blood platelet aggregation. Extreme cases of platelet responses to clopidogrel (ultra- vs. non-responder) were measured with miR-223-3p levels in leukocytes. Results: Both groups had similar miR-223-3p levels in leukocytes. There were no significant differences in other demographic and clinical data except for metrics of ADP-induced whole-blood platelet aggregation between the 2 group. Conclusion: MiR-223-3p in peripheral leukocytes is not associated with the altered platelet responses to clopidogrel in PCI outpatients.
探讨冠心病患者白细胞中miR-223水平与血小板对氯吡格雷反应之间的潜在相关性。
招募188例接受经皮冠状动脉介入治疗（PCI）并接受双联抗血小板治疗的门诊患者。收集患者的电子健康数据，并采集血样以测量二磷酸腺苷（ADP）诱导的全血血小板聚集。通过白细胞中miR-223-3p水平测定血小板对氯吡格雷反应的极端情况（超反应者与无反应者）。
两组白细胞中miR-223-3p水平相似。除两组之间ADP诱导的全血血小板聚集指标外，其他人口统计学和临床数据无显著差异。
外周血白细胞中的miR-223-3p与PCI门诊患者血小板对氯吡格雷反应的改变无关。
