Chen X H, Chen P J, Long Y, Huang Q P
Department of Otorhinolaryngology Head and Neck Surgery, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China.
Clinical Laboratory, Shenzhen Seventh People's Hospital.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 5;31(11):873-876. doi: 10.13201/j.issn.1001-1781.2017.11.013.
The aim of this study to investigate the determination and significance of serum MPO and amylin in adult patients with OSAHS after short-range noninvasive positive pressure ventilation. Eighty-seven OSAHS patients were divided into severe group (30 cases), moderate group (30 cases) and mild group (27 cases) according to the AHI range. Twenty-seven outpatient health persons were selected as the control group. Serum amylin and myeloperoxidase were measured by ELISA; Amyloid and myeloperoxidase were reassessed in 30 patients with severe OSAHS after 6 months of combined therapy, and the relationship between amylin, myeloperoxidase and PSG was analyzed. ①With the severity of OSAHS patients increased, the serum amylin and myeloperoxidase levels gradually increased (=22.486, 19.755;<0.01); There was no significant difference in MPO and amylin concentration between the mild group and the control group (>0.05), and the other groups were significantly different from each other (<0.01). ②There was no correlation among serum amylin and myeloperoxidase level and BMI and age in OSAHS patients (>0.05); and a negative correlation with SaO₂, and AHI was positively correlated (<0.01). ③After 3 months of CPAP treatment, LSaO₂ increased which the AHI and peripheral blood MPO, amylin levels lower than before in 30 patients (<0.05); The amylin and myeloperoxidase concentrations of blood after 6 months of treatment were significantly lower than those of 3 months after treatment (<0.05), which still increased compared with the control group. The determination of serum amylin and MPO in patients with OSAHS has a certain reference value in predicting the condition and curative effect of diabetes mellitus and insulin resistance. CPAP treatment can significantly reduce the degree of hypoxiapatients and cardiovascular damage in OSAHS patients, which was significantly correlated with the treatment time.
本研究旨在探讨成人阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者短期无创正压通气治疗后血清髓过氧化物酶（MPO）和胰淀素的测定及其意义。87例OSAHS患者根据睡眠呼吸暂停低通气指数（AHI）范围分为重度组（30例）、中度组（30例）和轻度组（27例）。选取27例门诊健康者作为对照组。采用酶联免疫吸附测定法（ELISA）检测血清胰淀素和髓过氧化物酶；对30例重度OSAHS患者联合治疗6个月后重新评估淀粉样蛋白和髓过氧化物酶，并分析胰淀素、髓过氧化物酶与多导睡眠图（PSG）之间的关系。①随着OSAHS患者病情严重程度增加，血清胰淀素和髓过氧化物酶水平逐渐升高（=22.486，19.755；<0.01）；轻度组与对照组MPO和胰淀素浓度比较差异无统计学意义（>0.05），其他各组间差异均有统计学意义（<0.01）。②OSAHS患者血清胰淀素和髓过氧化物酶水平与体质量指数（BMI）、年龄无相关性（>0.05）；与血氧饱和度（SaO₂）呈负相关，与AHI呈正相关（<0.01）。③30例患者经持续气道正压通气（CPAP）治疗3个月后，最低血氧饱和度（LSaO₂）升高，AHI及外周血MPO、胰淀素水平低于治疗前（<0.05）；治疗6个月后血液中胰淀素和髓过氧化物酶浓度明显低于治疗3个月时（<0.05），但仍高于对照组。测定OSAHS患者血清胰淀素和MPO对预测糖尿病及胰岛素抵抗的病情及疗效有一定参考价值。CPAP治疗可明显减轻OSAHS患者的低氧程度及心血管损害，且与治疗时间呈明显正相关。
