Xiao B, Liu J M, Wang Y K, Wu B, Chen X O
Department of Otorhinolaryngology Head and Neck Surgery, Deyang People's Hospital, Deyang, 618000, China.
Department of Otorhinolaryngology Head and Neck Surgery, the Eighth Affiliated Hospital, Sun-Yat-Sen University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Aug 20;31(16):1269-1272. doi: 10.13201/j.issn.1001-1781.2017.16.012.
To investigate the detection and significance of serum intercellular adhesion molecule-1 (ICAM-1) and myeloperoxidase (MPO) in elderly patients with OSAHS in adults.Ninety-three cases of elderly OSAHS patients who confirmed by PSG were observed. According to the range of AHI, they were divided into 3 groups (severe, moderate and mild). 31 cases of healthy person were observed as control group. The serum ICAM-1 and MPO were determined by ELISA method; ICAM-1 and MPO were measured after comprehensive treatment in patients with elderly severe OSAHS, and the correlation between ICAM-1, MPO and PSG were analyzed.①With the severity of snoring increased, the serum levels of ICAM-1 and MPO increased gradually (=29.937,18.946; < 0.01); The concentration of ICAM-1 and MPO in each group showed that there was no significant difference between the mild group and the control group (> 0.05), there were significant differences between the rest each two groups (< 0.05). ②There was no correlation between serum levels of ICAM-1, MPO, BMI, age in OSAHS patients (> 0.05). There was a positively relationship between ICAM-1 and MPO . Both of them were negatively correlated with AHI, and positively correlated with LSaO2 (< 0.01). ③The concentration of ICAM-1, MPO and AHI in 31 elderly patients with severe OSAHS decreased and LSaO₂ increased significantly after 3 months of comprehensive treatment (< 0.01).The increase of ICAM-1 and MPO concentration in peripheral blood is one of the mechanisms of cardiovascular damage in elderly patients with OSAHS. Determination of peripheral blood ICAM-1, MPO levels in elderly patients with OSAHS to help determine the severity of disease, the evaluation of treatment,which may have a certain reference value for the prediction of cardiovascular disease risk in patients with severe OSAHS.
探讨血清细胞间黏附分子-1（ICAM-1）和髓过氧化物酶（MPO）在成年老年阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者中的检测情况及意义。观察93例经多导睡眠监测（PSG）确诊的老年OSAHS患者。根据呼吸暂停低通气指数（AHI）范围，将其分为3组（重度、中度和轻度）。观察31例健康人作为对照组。采用酶联免疫吸附测定（ELISA）法测定血清ICAM-1和MPO；对老年重度OSAHS患者进行综合治疗后测定ICAM-1和MPO，并分析ICAM-1、MPO与PSG之间的相关性。①随着打鼾严重程度增加，血清ICAM-1和MPO水平逐渐升高（=29.937，18.946；<0.01）；各组ICAM-1和MPO浓度显示，轻度组与对照组之间差异无统计学意义（>0.05），其余各组两两之间差异有统计学意义（<0.05）。②OSAHS患者血清ICAM-1、MPO水平与体重指数（BMI）、年龄之间无相关性（>0.05）。ICAM-1与MPO呈正相关。二者均与AHI呈负相关，与最低血氧饱和度（LSaO2）呈正相关（<0.01）。③31例老年重度OSAHS患者综合治疗3个月后，ICAM-1、MPO浓度及AHI降低，LSaO₂显著升高（<0.01）。外周血ICAM-1和MPO浓度升高是老年OSAHS患者心血管损害的机制之一。检测老年OSAHS患者外周血ICAM-1、MPO水平有助于判断病情严重程度、评估治疗效果，对预测重度OSAHS患者心血管疾病风险可能有一定参考价值。
