Department of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Lipids Health Dis. 2018 May 17;17(1):117. doi: 10.1186/s12944-018-0771-z.
To investigate the association between the ratio of apolipoprotein B (apo B) / apolipoprotein A1 (apo A1) with all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients.
Eight hundred and sixty incident PD patients were enrolled from November 1, 2005, to February 28, 2017, and followed until May 31, 2017. Outcomes were all-cause mortality and cardiovascular events. Associations between the apo B/apo A1 ratio with all-cause mortality and cardiovascular events were evaluated using multivariable-adjusted Cox models.
Of the 860 patients, the mean age was 49.9 ± 14.5 years, 57.6% were men, and 19.3% were diabetic patients. The median apo B/apo A1 ratio was 0.65 (range: 0.22-2.24). During a median follow-up period of 27 months (interquartile range, 13 - 41 months), 202 deaths, and 145 cardiovascular events were recorded. After adjustment for age, sex, body mass index, diabetes, cardiovascular disease, systolic blood pressure, total Kt/V, estimated glomerular filtration rate, hemoglobin level, neutrophil to lymphocyte ratio and albumin, triglyceride, and cholesterol, as well as the use of lipid-lowering agents, the highest apo B/apo A1 ratio tertile was significantly associated with a hazard ratio for all-cause mortality of 1.60 (95% CI: 1.02 to 2.49, P = 0.040) and for cardiovascular events of 2.04 (95% CI: 1.21 to 3.44, P = 0.008).
An increased apo B/apo A1 ratio was independently associated with all-cause mortality and cardiovascular events in PD patients.
研究载脂蛋白 B（apo B）/载脂蛋白 A1（apo A1）比值与腹膜透析（PD）患者全因死亡率和心血管事件的关系。
2005 年 11 月 1 日至 2017 年 2 月 28 日期间共纳入 860 例首发 PD 患者，并随访至 2017 年 5 月 31 日。结局为全因死亡率和心血管事件。采用多变量调整 Cox 模型评估 apo B/apo A1 比值与全因死亡率和心血管事件的关系。
860 例患者中，平均年龄为 49.9±14.5 岁，57.6%为男性，19.3%为糖尿病患者。apo B/apo A1 比值中位数为 0.65（范围：0.22-2.24）。中位随访 27 个月（四分位间距 13-41 个月）期间，记录到 202 例死亡和 145 例心血管事件。在调整年龄、性别、体重指数、糖尿病、心血管疾病、收缩压、总 Kt/V、估计肾小球滤过率、血红蛋白水平、中性粒细胞与淋巴细胞比值、白蛋白、甘油三酯和胆固醇以及降脂药物使用后，apo B/apo A1 比值最高三分位数与全因死亡率的风险比为 1.60（95%CI：1.02 至 2.49，P=0.040）和心血管事件的风险比为 2.04（95%CI：1.21 至 3.44，P=0.008）。
apo B/apo A1 比值升高与 PD 患者全因死亡率和心血管事件独立相关。
