Taguchi Takura, Nishi Hiroyuki, Kurose Kimihiro, Horikawa Kohei, Kanazawa Go, Takahashi Toshiki
Department of Cardiovascular Surgery, Osaka Police Hospital, 10-31, Kitayama-cho, Tennoji-ku, Osaka, 543-0035, Japan.
J Cardiothorac Surg. 2018 May 18;13(1):45. doi: 10.1186/s13019-018-0730-9.
Cardiac surgery for myelodysplastic syndrome (MDS) patients is challenging because anemia and neutropenia develop as a result of the syndrome, leading to infection and bleeding tendency during surgery. We report the case of minimally invasive mitral valve repair via a right mini-thoracotomy and perioperative use of granulocyte colony-stimulating factor (G-CSF) in a patient with MDS.
A 77-year-old man with myelodysplastic syndrome (MDS) was referred for surgical treatment for mitral valve regurgitation and underwent a minimally invasive mitral valve repair via a right mini-thoracotomy (MICS mitral procedure). On admission, laboratory results showed a leukocyte count of 1500/μL and neutrophils at 190/μL. Prior to surgery, a subcutaneous injection of granulocyte colony-stimulating factor (G-CSF) was given, based on a diagnosis of MDS by a hematologist. The MICS-mitral procedure using artificial chordae and an annular ring prosthesis was completed without requiring re-exploration for bleeding. Postoperatively, a G-CSF injection was administered and transfusion was required. There was no infection complication and the postoperative course was uneventful.
A MICS-mitral procedure may be an effective option for MR patients with MDS who require a mitral valve repair to avoid postoperative infection and reduce the incidence of perioperative transfusion.
对于骨髓增生异常综合征(MDS)患者进行心脏手术具有挑战性,因为该综合征会导致贫血和中性粒细胞减少,进而在手术期间引发感染和出血倾向。我们报告了一例通过右胸小切口进行微创二尖瓣修复并在围手术期使用粒细胞集落刺激因子(G-CSF)治疗的MDS患者。
一名77岁的骨髓增生异常综合征(MDS)男性患者因二尖瓣反流接受手术治疗,通过右胸小切口进行了微创二尖瓣修复术(MICS二尖瓣手术)。入院时,实验室检查结果显示白细胞计数为1500/μL,中性粒细胞为190/μL。手术前,血液科医生根据MDS的诊断给予皮下注射粒细胞集落刺激因子(G-CSF)。使用人工腱索和环形瓣环假体完成了MICS二尖瓣手术,无需因出血而再次开胸探查。术后,给予G-CSF注射并需要输血。没有感染并发症,术后过程顺利。
对于需要进行二尖瓣修复的MDS合并二尖瓣反流患者,MICS二尖瓣手术可能是一种有效的选择,可避免术后感染并降低围手术期输血发生率。