Marino Patricia, Bannier Marie, Moulin Jean-François, Gravis Gwenaëlle
Institut Paoli-Calmettes, SESSTIM UMR912, 232, boulevard Sainte-Marguerite, 13009 Marseille, France; Aix-Marseille université, Inserm, IRD, SESSTIM sciences économiques et sociales de la santé et traitement de l'information médicale, 13009 Marseille, France.
Institut Paoli-Calmettes, département de chirurgie oncologique, 232, boulevard Sainte-Marguerite, 13009 Marseille, France.
Bull Cancer. 2018 Jun;105(6):603-609. doi: 10.1016/j.bulcan.2018.02.008.
Therapeutic innovations in the field of oncology allow to manage cancer as a chronic illness with treatments being administered over prolonged periods of time. In this context, it is now acknowledged that it is important to complete the assessment of benefit based on purely clinical endpoints using outcome measurement evaluated by patients themselves. The Patient reported outcome (PRO) concept has then emerged and there is an increasing interest in using the PROs as an indicator of the benefit of new therapeutic strategies. In this paper, we aim to illustrate the potential use and value of using PROs in the management of cancer patients. After a brief review of the PRO concept and it's link with the quality-of-life concept, this paper describes the actual implementation of PROs, first in clinical research, then in routine clinical practice. We then will focus on the difficulties in the French context to promote a larger use of PROs in the routine clinical practice. This paper will show how the PROs are a useful tool to improve the management of cancer patients.
肿瘤学领域的治疗创新使得癌症能够作为一种慢性病来管理，治疗需长期进行。在此背景下，人们现在认识到，基于患者自身评估的结果测量，使用纯粹的临床终点来完成获益评估非常重要。于是出现了患者报告结局（PRO）的概念，并且越来越关注将PRO用作新治疗策略获益的指标。在本文中，我们旨在阐述在癌症患者管理中使用PRO的潜在用途和价值。在简要回顾PRO概念及其与生活质量概念的联系之后，本文描述了PRO在临床研究中的实际应用，然后是在常规临床实践中的应用。接着我们将关注在法国背景下在常规临床实践中推广更广泛使用PRO的困难。本文将展示PRO如何成为改善癌症患者管理的有用工具。
