从神经发育到神经退行性病变追踪环境暴露
Tracing Environmental Exposure from Neurodevelopment to Neurodegeneration.
机构信息
Melbourne Dementia Research Centre at The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Parkville, VIC, Australia.
Melbourne Dementia Research Centre at The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Parkville, VIC, Australia; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, Australia.
出版信息
Trends Neurosci. 2018 Aug;41(8):496-501. doi: 10.1016/j.tins.2018.04.005. Epub 2018 May 15.
Interplay between genetic and environmental factors during critical time windows can have effects that span from neurodevelopment to neurodegeneration. We present the concept of the 'neuroexposome', emphasizing the brain's distinctive response to environmental exposure, and how current 'omics' sciences can inform on both disease pathogenesis and future public health policies.
遗传和环境因素在关键时间窗内的相互作用可能会产生从神经发育到神经退行性变的影响。我们提出了“神经外显组”的概念，强调了大脑对环境暴露的独特反应，以及当前的“组学”科学如何为疾病发病机制和未来的公共卫生政策提供信息。
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