Shuayb Md, Reza Md Salim
Square Oncology and Radiotherapy Centre, Square Hospitals, Dhaka, Bangladesh.
BMJ Support Palliat Care. 2019 Mar;9(1):51-53. doi: 10.1136/bmjspcare-2018-001559. Epub 2018 May 18.
Despite the fact that multiple primary malignancies (MPMs) are not new and have been diagnosed for about a hundred-year time, literatures on lung and colon primaries are scarce. We report a case of a 62-year-old Asian Bangladeshi man with stage IV lung adenocarcinoma who developed a metachronous stage II colon adenocarcinoma approximately 3 years later. A chemotherapy protocol of six cycles of pemetrexed/cisplatin followed by maintenance pemetrexed was used, and surgery was done for the colon primary. With more than 5 years of periodic follow-up, his disease remains stable without any local or metastatic recurrence. Definitive therapeutic protocols are unavailable, but information taken with caution from case reports may be of importance for treatment decisions of MPMs. We believe that management with careful judgement by a multidisciplinary team may result in a good outcome with longer survival.
尽管多原发性恶性肿瘤（MPMs）并非新鲜事物，且已被诊断约百年，但关于肺和结肠原发性肿瘤的文献却很稀少。我们报告一例62岁的亚洲孟加拉男性，患有IV期肺腺癌，约3年后出现异时性II期结肠腺癌。采用了培美曲塞/顺铂六个周期化疗方案，随后进行培美曲塞维持治疗，并对结肠原发性肿瘤进行了手术。经过5年多的定期随访，他的病情保持稳定，无任何局部或转移复发。目前尚无明确的治疗方案，但从病例报告中谨慎获取的信息可能对MPMs的治疗决策具有重要意义。我们认为，由多学科团队进行谨慎判断的管理可能会带来良好的结果和更长的生存期。
