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二甲双胍作用机制：肠内与肠外。

Mechanisms of metformin action: In and out of the gut.

机构信息

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.

出版信息

J Diabetes Investig. 2018 Jul;9(4):701-703. doi: 10.1111/jdi.12864. Epub 2018 Jun 5.

DOI:10.1111/jdi.12864
PMID:29777629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6031513/
Abstract

Recent evidence suggests that metformin exerts glucose-lowering effects via its action in the gut. The accumulation in the colon of F-labeled fluorodeoxyglucose (FDG), a nonmetabolizable derivative of glucose, is markedly augmented after metformin administration, indicating that metformin affects the handling of glucose in colon whereas the underlying mechanism and the significance to glucose metabolism of the finding remain to be determined.

摘要

最近的证据表明，二甲双胍通过其在肠道中的作用发挥降血糖作用。在给予二甲双胍后， F 标记的氟脱氧葡萄糖（FDG），葡萄糖的不可代谢衍生物，在结肠中的积累明显增加，这表明二甲双胍影响结肠对葡萄糖的处理，而其潜在机制和对葡萄糖代谢的意义仍有待确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13fa/6031513/4c07332876af/JDI-9-701-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13fa/6031513/479110a58f37/JDI-9-701-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13fa/6031513/4c07332876af/JDI-9-701-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13fa/6031513/479110a58f37/JDI-9-701-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13fa/6031513/4c07332876af/JDI-9-701-g002.jpg

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本文引用的文献

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2
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Nat Med. 2017 Jul;23(7):850-858. doi: 10.1038/nm.4345. Epub 2017 May 22.
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Metformin discontinuation less than 72 h is suboptimal for F-18 FDG PET/CT interpretation of the bowel.
Signal Transduct Target Ther. 2023 Oct 9;8(1):386. doi: 10.1038/s41392-023-01619-w.
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Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort.二甲双胍单药治疗改变 2 型糖尿病临床队列中人类血浆脂质组，独立于血糖控制和心血管疾病风险的临床标志物。
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