Thune P, Jansén C, Wennersten G, Rystedt I, Brodthagen H, McFadden N
Ullevaal Hospital, Oslo, Norway.
Photodermatol. 1988 Dec;5(6):261-9.
At 16 different dermatology clinics in Scandinavia from 1980-1985, photopatch testing was performed on 1993 patients with suspected photodermatosis. The collective results are presented in this article. The most common cause of sun-related dermatosis was polymorphic light eruption (PLE) (38%), while secondary aggravation of pre-existing skin diseases was established in 16% of the patient group. Photocontact dermatitis (11%) and contact dermatitis (10%) were responsible for 274 and 369 positive test reactions (respectively) on photopatch testing using the SPDRG standard series. Musk ambrette and para-aminobenzoic acid were the leading photosensitizers, while perfume mixture, balsam of Peru and lichen mixture were the most frequent causes of contact sensitivity. The principal photoallergens and contact allergens in the PLE, persistent light reaction and actinic reticuloid groups are discussed, together with the problems, risks and possible mechanisms of induction of photosensitization in these patients. The incidence, causes and diagnostic and therapeutic implications of secondary sunscreen sensitivity in these groups are also addressed.
1980年至1985年期间，在斯堪的纳维亚半岛的16家不同皮肤科诊所，对1993例疑似光皮肤病患者进行了光斑贴试验。本文展示了总体结果。与阳光相关的皮肤病最常见病因是多形性日光疹（PLE）（38%），而16%的患者组存在既往皮肤疾病的继发性加重情况。在使用SPDRG标准系列进行的光斑贴试验中，光接触性皮炎（11%）和接触性皮炎（10%）分别导致了274例和369例阳性试验反应。葵子麝香和对氨基苯甲酸是主要的光敏剂，而香料混合物、秘鲁香脂和地衣混合物是接触致敏最常见的原因。文中讨论了PLE、持久性光反应和光化性类网状细胞增多症组中的主要光变应原和接触变应原，以及这些患者中光敏化诱导的问题、风险和可能机制。还讨论了这些组中继发性防晒剂敏感性的发生率、病因以及诊断和治疗意义。
