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直肠癌术前放疗或放化疗——是否能提高生存率？不可切除癌症中“北欧”LARC 研究的更新。

Preoperative radiotherapy or chemoradiotherapy in rectal cancer - Is survival improved? An update of the "Nordic" LARC study in non-resectable cancers.

机构信息

Section of Gastrointestinal Oncology, Department of Oncology, Oslo University Hospital, Oslo, Norway.

Section of Experimental and Clinical Oncology, Department of Immunology, Genetics & Pathology, Uppsala University, Uppsala, Sweden.

出版信息

Radiother Oncol. 2018 Jun;127(3):392-395. doi: 10.1016/j.radonc.2018.05.004. Epub 2018 May 16.

DOI:10.1016/j.radonc.2018.05.004
PMID:29778486
Abstract

The randomized "Nordic" LARC study compared preoperative long-course radiotherapy alone (RT) or with chemotherapy (CRT) in the most locally advanced/ugly rectal cancers. Despite significantly better local control in the CRT group, no overall survival benefit was seen after 10 years follow-up. The relations between local control and survival are discussed.

摘要

随机化的“北欧”LARC 研究比较了术前单纯长程放疗（RT）或放化疗（CRT）在局部晚期/晚期直肠癌中的应用。尽管 CRT 组的局部控制明显更好，但在 10 年随访后并未观察到总体生存获益。文中讨论了局部控制与生存之间的关系。

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