Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Biochem Biophys Res Commun. 2018 Jul 7;502(1):62-68. doi: 10.1016/j.bbrc.2018.05.121. Epub 2018 May 24.
Diabetes affects cardiac structure and function, where it leads to diabetic cardiomyopathy. Reactive oxygen species (ROS) produced by oxidative stress play an important role in the development of diabetic cardiomyopathy. Fibroblast growth factor (FGF) 19, an enterokine, is synthesized and released into the ileum. In the present study, we revealed that FGF19 induced an antioxidant response through stimulating the expression of nuclear erythroid factor 2 (NE-F2)-related factor 2 (Nrf2) and as well as reducing ROS production through the AMPK signaling pathway. Additionally, AMPK inhibition by the AMPK-specific inhibitor compound C decreased Nrf2 and heme oxygenase-1 (HO-1) protein expression. Taken together, these results suggested that FGF19, through the anti-oxidative defense system, attenuated the development of diabetic cardiomyopathy and restored cardiac function.
糖尿病影响心脏结构和功能，导致糖尿病心肌病。氧化应激产生的活性氧（ROS）在糖尿病心肌病的发展中起重要作用。成纤维细胞生长因子（FGF）19 是一种肠激素，在回肠中合成并释放。在本研究中，我们揭示了 FGF19 通过刺激核红细胞因子 2（NE-F2）相关因子 2（Nrf2）的表达诱导抗氧化反应，同时通过 AMPK 信号通路减少 ROS 的产生。此外，AMPK 特异性抑制剂化合物 C 抑制 AMPK 会降低 Nrf2 和血红素加氧酶-1（HO-1）蛋白的表达。总之，这些结果表明，FGF19 通过抗氧化防御系统减轻了糖尿病心肌病的发展并恢复了心脏功能。
