First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, 108 Vas. Sofias Ave, 11527, Athens, Greece.
Curr Hypertens Rep. 2018 May 19;20(6):49. doi: 10.1007/s11906-018-0847-1.
To summarize the evidence regarding the distribution of renal nerves and their patterns of anatomic variations in animal and human settings. Moreover, the methodology and results of studies regarding renal nerve stimulation (RNS) in both preclinical and clinical models are presented.
There are differences regarding the number and the size of renal fibers, as well as their distance from the lumen in the diverse parts of the main renal arteries and the branches. In both animals and humans, RNS is safe and results in an increase of blood pressure (BP) while the effect on heart rate varies. In this context, the ConfidenHT™ system constitutes an integrated solution for effective RNS in humans. Due to the diversity of renal nerve anatomy in humans, arterial areas for more effective renal denervation cannot be homogenously defined. The concept of mapping of renal nerves can improve completeness of renal denervation therapies by means of integrated RNS solutions such as the ConfidenHT™ system.
总结动物和人体环境中肾神经的分布及其解剖变异模式的证据。此外，还介绍了临床前和临床模型中肾神经刺激（RNS）的研究方法和结果。
主肾动脉及其分支的不同部位的肾纤维数量和大小以及它们与管腔的距离存在差异。在动物和人类中，RNS 是安全的，会导致血压升高，而对心率的影响则不同。在这种情况下，ConfidenHT™系统构成了人类有效 RNS 的综合解决方案。由于人类肾神经解剖的多样性，不能均匀地定义更有效的肾去神经支配的动脉区域。肾神经映射的概念可以通过 ConfidenHT™系统等综合 RNS 解决方案来提高肾去神经支配治疗的完整性。
