Muhammad Jibran Sualeh, Ishaq Muhammad, Ahmed Khalid
Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Department of Internal Medicine, Jinnah Medical College Hospital, Korangi, Karachi, Pakistan.
Curr Rheumatol Rev. 2019;15(1):7-13. doi: 10.2174/1573397114666180521090335.
Behçet's Disease (BD) is characterized by numerous systemic manifestations and is known for its ability to affect both, arteries and the veins. However, the etiology of BD is only partially understood, and previous studies have demonstrated a role for genetic and epigenetic factors that contribute to disease pathophysiology. Several studies have implicated T cells and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock proteins and streptococcal antigen. Furthermore, during disease exacerbations adenosine deaminase has an important role in activating lymphocyte proliferation, maturation, and differentiation in BD. This article presents a review of the published literature mainly from the last 20 years. The topics of main concern were the role of genetic and epigenetic factors as contributing factors in disease pathophysiology.
The authors used MeSH terms "Behçet's disease" with "pathophysiology," "pathogenesis," "genetic" or "epigenetic" to search the PubMed database. All the relevant studies identified were included and are described according to the aforementioned subheadings.
白塞病（BD）具有多种全身表现，以其累及动脉和静脉的能力而闻名。然而，BD的病因仅得到部分理解，先前的研究已证明遗传和表观遗传因素在疾病病理生理学中发挥作用。多项研究表明T细胞和单核细胞在BD的发病机制中起作用，尤其是当这些细胞受到热休克蛋白和链球菌抗原刺激时。此外，在疾病加重期间，腺苷脱氨酶在激活BD中淋巴细胞的增殖、成熟和分化方面具有重要作用。本文主要对过去20年发表的文献进行综述。主要关注的主题是遗传和表观遗传因素在疾病病理生理学中作为促成因素的作用。
作者使用医学主题词“白塞病”与“病理生理学”“发病机制”“遗传”或“表观遗传”来检索PubMed数据库。纳入所有识别出的相关研究，并根据上述小标题进行描述。
