Ma Xiaomin, Wang Xin, Zheng Guangbing, Tan Guiqin, Zhou Fangyu, Wei Wenwen, Tian Dan, Yu Hongsong
School of Basic Medical Sciences, Special Key Laboratory of Ocular Diseases of Guizhou Province, Zunyi Medical University, Guizhou, China.
Front Cell Dev Biol. 2021 Oct 5;9:719235. doi: 10.3389/fcell.2021.719235. eCollection 2021.
Behçet's disease (BD) is a chronic refractory multisystem autoinflammatory disease, characterized by typical clinical features of non-specific vasculitis, oral and genital ulcers, uveitis, as well as skin lesions. The exact etiopathogenesis of BD remains unknown, existing studies have indicated that genetics and environmental factors contribute to the increased development of BD. Recently, several studies have shown that external environmental factors can affect the process of epigenetic modification, and abnormalities of epigenetic factors have been confirmed to be involved in the occurrence of BD. At the same time, abnormalities of gut microbiota (GM) in the body, have also been confirmed to participate in the pathogenesis of BD by regulating the balance of Th17/Tregs. This article reviews the pathogenesis of BD and summarizes numerous clinical studies, focusing on the mechanism of GM and epigenetic factors impacting on BD, and providing new ideas for further elucidating the pathogenesis of BD.
白塞病（BD）是一种慢性难治性多系统自身炎症性疾病，其特征为非特异性血管炎、口腔和生殖器溃疡、葡萄膜炎以及皮肤病变等典型临床特征。BD的确切病因仍不清楚，现有研究表明，遗传和环境因素促使BD的发病率增加。最近，多项研究表明，外部环境因素可影响表观遗传修饰过程，并且已证实表观遗传因素异常与BD的发生有关。同时，体内肠道微生物群（GM）异常也已被证实在通过调节Th17/Tregs平衡参与BD的发病机制。本文综述了BD的发病机制并总结了大量临床研究，重点关注GM和表观遗传因素影响BD的机制，为进一步阐明BD的发病机制提供新思路。
