Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):329-340. doi: 10.1016/j.beem.2018.02.006. Epub 2018 Feb 27.
Increasing attention is being focused on the important contributions of cortical bone to bone strength, fractures and osteoporosis therapies. Recent progress in human genome wide association studies in combination with high-throughput mouse gene knockout phenotyping efforts of multiple genes and advanced conditional gene inactivation in mouse models have successfully identified genes with crucial roles in cortical bone homeostasis. Particular attention in this review is given to genes, such as WNT16, POSTN and SFRP4, that differentially affect cortical and trabecular bone architecture. We propose that animal models of cortical bone metabolism will substantially contribute to developing anabolic osteoporosis therapies that improve cortical bone mass and reduce non-vertebral fracture risk.
越来越多的人开始关注皮质骨对骨骼强度、骨折和骨质疏松症治疗的重要贡献。近年来，人类全基因组关联研究取得了进展，结合高通量小鼠基因敲除表型分析和多种基因的先进条件性基因敲除小鼠模型，成功鉴定出了在皮质骨稳态中起关键作用的基因。本文特别关注了一些基因，如 WNT16、POSTN 和 SFRP4，它们对皮质骨和小梁骨结构有不同的影响。我们提出，皮质骨代谢的动物模型将为开发能够增加皮质骨量、降低非椎体骨折风险的合成代谢性骨质疏松症治疗方法做出重大贡献。
