[肿瘤促进机制]
[Mechanism of tumor promotion].
作者信息
Nishino H
机构信息
Département de Biochimie, Université Médicale de la Préfecture de Kyoto, Japon.
出版信息
C R Seances Soc Biol Fil. 1988;182(4):439-44.
PMID:2977964
Abstract
Various kinds of calmodulin-interacting agents have been proved to suppress tumor promotion in vivo. In this study, we further demonstrate that flunarizine and dehydroepiandrosterone, which are proved to interact with calmodulin, showed antitumor-promoting activity in two-stage carcinogenesis of mouse skin. These results indicate that Ca2+/-calmodulin system, may play an important role in tumor promotion.
摘要
已证实多种钙调蛋白相互作用剂在体内可抑制肿瘤促进作用。在本研究中，我们进一步证明，已证实与钙调蛋白相互作用的氟桂利嗪和脱氢表雄酮在小鼠皮肤两阶段致癌过程中显示出抗肿瘤促进活性。这些结果表明，Ca2+/钙调蛋白系统可能在肿瘤促进中起重要作用。
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