Departamento de Ingeniería Eléctrica, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.
Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.
Arch Med Res. 2018 Feb;49(2):89-93. doi: 10.1016/j.arcmed.2018.04.012. Epub 2018 May 17.
In this work, the multi-frequency impedance both in normal and liver cancer tissues was studied. This was to investigate the feasibility to detect liver cancer by a low cost, easy to use, and a relatively non-invasive electrical impedance measure technique, and thus potentially improving liver cancer diagnosis.
Hepatocellular carcinoma (HCC) was induced in male Wistar rats by the administration of diethylnitrosamine (DEN) during 16 weeks. The electrical impedances at a frequency sweep of 10-100 KHz in the whole body and 10-60 KHz in the liver were taken at the end of the treatment.
The electrical impedance showed that the real component values of the impedance change in HCC. In addition, we found that the imaginary component was not associated with HCC.
Our results suggest that the electrical impedance may be used as a diagnostic HCC tool.
本研究旨在探讨多频阻抗在正常组织和肝癌组织中的变化，旨在探索一种低成本、易于使用、相对非侵入性的电阻抗测量技术来检测肝癌的可行性，从而提高肝癌的诊断率。
雄性 Wistar 大鼠通过给予二乙基亚硝胺（DEN）16 周诱导肝细胞癌（HCC）。在治疗结束时，在全身 10-100kHz 和肝脏 10-60kHz 的频率扫描中获取电阻抗。
电阻抗显示 HCC 患者的阻抗实部值发生变化。此外，我们发现虚部值与 HCC 无关。
我们的结果表明，电阻抗测量可能可作为 HCC 的诊断工具。
