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新生儿和婴儿先天性心脏手术后早期肠内营养的可行性

Feasibility of initiating early enteral nutrition after congenital heart surgery in neonates and infants.

作者信息

Kalra Rajat, Vohra Rohit, Negi Malti, Joshi Reena, Aggarwal Neeraj, Aggarwal Mridul, Joshi Raja

机构信息

Pediatric Cardiac Sciences, Sir Ganga Ram Hospital, New Delhi, 110060, India.

Pediatric Cardiac Sciences, Sir Ganga Ram Hospital, New Delhi, 110060, India.

出版信息

Clin Nutr ESPEN. 2018 Jun;25:100-102. doi: 10.1016/j.clnesp.2018.03.127. Epub 2018 Apr 12.

Abstract

OBJECTIVE

To assess the feasibility of initiating enteral nutrition support with first 24 h of congenital heart repairs in neonates and Infants and its impact on outcomes following surgery.

DESIGN

It is a prospective randomized control single blind study.

SETTING

It is a single centre prospective study carried out in a tertiary care centre at Pediatric cardiac intensive care unit.

PATIENTS

All patients with the cyanotic congenital heart disease with increase pulmonary blood flow, weighing less than 5 kg and undergoing congenital heart repair during the study period were included in the study. Patients with single ventricle status, those undergoing palliative procedures (PA band), open chest, requiring ECMO before leaving operating room, having any other contraindication for starting enteral feeding or those who refuse for consent were excluded from study.

INTERVENTIONS

The patients were randomized into two groups. Group 1 received trophic feeds (10-20 ml/kg/day) starting 4-6 h after surgery while feeds children in group 2 were kept NPO and received feeds after 48 h after surgery.

MEASUREMENTS AND MAIN RESULTS

15 children enrolled in both the groups. Both pre-operative and intraoperative variables were comparable in both the groups. There was no complication (vomiting, diarrhea, NEC, bowel necrosis) noted in the children who received feeds after surgery. Mean duration of mechanical ventilation in the feeds group was 58.2 ± 4.71 h, which was less then significantly less than those in the NPO group (P value 0.05). Similarly, duration of ICU stay was only 179.04 ± 41.28 h in feeds group as compared to 228.72 ± 85.44 h in the NPO group.

CONCLUSIONS

Neonates and Infants tolerate feeds immediately following congenital heart repairs. Moreover, feeds appear to decrease duration of mechanical ventilation and duration of ICU stay.

摘要

目的

评估在新生儿和婴儿先天性心脏病修复术后最初24小时内开始肠内营养支持的可行性及其对术后结局的影响。

设计

这是一项前瞻性随机对照单盲研究。

背景

这是在一家三级护理中心的儿科心脏重症监护病房进行的单中心前瞻性研究。

患者

所有在研究期间患有肺血流量增加的青紫型先天性心脏病、体重小于5千克且正在接受先天性心脏病修复术的患者均纳入研究。单心室状态的患者、接受姑息性手术(肺动脉环扎术)的患者、开胸手术患者、在离开手术室前需要体外膜肺氧合的患者、有任何其他开始肠内喂养的禁忌症的患者或拒绝同意的患者被排除在研究之外。

干预措施

将患者随机分为两组。第1组在术后4 - 6小时开始接受微量喂养(10 - 20毫升/千克/天),而第2组的患儿术后禁食,术后48小时后开始喂养。

测量指标及主要结果

两组均有15名儿童入组。两组术前和术中变量具有可比性。术后接受喂养的儿童未出现并发症(呕吐、腹泻、坏死性小肠结肠炎、肠坏死)。喂养组机械通气的平均持续时间为58.2±4.71小时,显著短于禁食组(P值0.05)。同样,喂养组的重症监护病房住院时间仅为179.04±41.28小时,而禁食组为228.72±85.44小时。

结论

新生儿和婴儿在先天性心脏病修复术后能立即耐受喂养。此外,喂养似乎可缩短机械通气时间和重症监护病房住院时间。

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