Bibi H, Schlesinger M, Shapira H, Schwartz Y, Fink A, Tabachnik E
Department of Pediatrics, Barzilai Medical Center, Ashkelon, Israel.
Int J Tissue React. 1988;10(5):305-10.
Measurements of cellular immunity including the percentage of T-cell mitogenic response of lymphocytes to phytohemagglutinin (PHA) and concanavalin A (Con A), as well as Con A-induced suppressor function, were determined in 20 asthmatic children (mean age 12.4 +/- 0.6 years) before and after 6 months of theophylline therapy. Only 9 of the 20 children patients that commenced the study completed the entire 6 months of therapy. A group of 37 healthy children (mean age 12.6 +/- 0.3 years) served as control. During the 6-month period of therapy, theophylline levels were maintained between 10 and 20 micrograms%. No significant difference in any of the parameters examined were found between the initial 20 asthmatic patients and the control group. Furthermore, in the 9 patients that were evaluated before and after 6 months of theophylline therapy no significant change in lymphocyte function including suppressor function was detected. We conclude that the beneficial effect of long-term theophylline therapy in asthmatic children is probably not related to an immuno-modulatory effect.
对20名哮喘儿童（平均年龄12.4±0.6岁）在茶碱治疗6个月前后进行了细胞免疫测量，包括淋巴细胞对植物血凝素（PHA）和刀豆球蛋白A（Con A）的T细胞促有丝分裂反应百分比，以及Con A诱导的抑制功能。开始该研究的20名儿童患者中只有9名完成了整个6个月的治疗。37名健康儿童（平均年龄12.6±0.3岁）作为对照组。在6个月的治疗期间，茶碱水平维持在10至20微克%之间。在最初的20名哮喘患者和对照组之间，在所检查的任何参数上均未发现显著差异。此外，在9名接受6个月茶碱治疗前后评估的患者中，未检测到包括抑制功能在内的淋巴细胞功能有显著变化。我们得出结论，长期茶碱治疗对哮喘儿童的有益作用可能与免疫调节作用无关。
