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[茶碱在淋巴细胞培养中的免疫调节特性研究]

[Study of the immunotropic properties of theophylline in lymphocyte culture].

作者信息

Sokolov E I, Glan P V, Sashkina T I

出版信息

Farmakol Toksikol. 1989 Jul-Aug;52(4):67-70.

PMID:2530107
Abstract

The effect of theophylline on the activation of suppressor cells by histamine was studied in the experiments with mononuclear cells of blood of patients with bronchial asthma and healthy donors. Theophylline (1-5 micrograms/ml) was shown to be able of activating suppressed function of cells of the patients. Incubation of mononuclear cells of the healthy donors with theophylline did not change the process of suppressor formation in vitro.

摘要

在对支气管哮喘患者和健康供体的血液单核细胞进行的实验中,研究了茶碱对组胺激活抑制细胞的作用。已表明茶碱(1 - 5微克/毫升)能够激活患者细胞的抑制功能。健康供体的单核细胞与茶碱一起孵育,在体外并未改变抑制细胞的形成过程。

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1
[Study of the immunotropic properties of theophylline in lymphocyte culture].[茶碱在淋巴细胞培养中的免疫调节特性研究]
Farmakol Toksikol. 1989 Jul-Aug;52(4):67-70.
2
Effect of in vitro colchicine and oral theophylline on suppressor cell function of asthmatic patients.体外秋水仙碱和口服茶碱对哮喘患者抑制细胞功能的影响。
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Cellular immunity and suppressor T cell function in asthmatic children on prolonged theophylline therapy.长期接受茶碱治疗的哮喘儿童的细胞免疫和抑制性T细胞功能
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Characterization of human effector and suppressor T cells by their activity in mixed lymphocyte reaction and by monoclonal antibody phenotyping.通过混合淋巴细胞反应中的活性及单克隆抗体表型分析对人效应性和抑制性T细胞进行鉴定。
J Clin Lab Immunol. 1983 Dec;12(4):217-20.
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Suppressor, helper and immunoregulatory T cells in normal human blood as defined by theophylline sensitivity.
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[Suppressor hyperactivity in relation to allogeneic lymphocyte proliferation as a manifestation of T- T-cell interaction defects in systemic lupus erythematosus].[作为系统性红斑狼疮中T-T细胞相互作用缺陷表现的与同种异体淋巴细胞增殖相关的抑制因子活性亢进]
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Plasma from insulin-dependent diabetics inhibits theophylline sensitive T-lymphocytes demonstrated in E-rosette assay.
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