茶碱对哮喘患儿T抑制细胞比例及功能的影响。
Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children.
作者信息
Lahat N, Nir E, Horenstien L, Colin A A
出版信息
Allergy. 1985 Aug;40(6):453-7. doi: 10.1111/j.1398-9995.1985.tb02685.x.
T-cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy. A decreased proportion and function of theophylline-sensitive T-suppressor cells was found in fresh peripheral blood of asthmatic children. Following peripheral blood mononuclear cells (PBMC) incubation in theophylline-free medium, the proportion of theophylline-sensitive T-cells in asthmatic children treated with theophylline was elevated to normal values. However, their suppressive effect on control lymphocyte proliferation was unchanged.
对接受或未接受茶碱治疗的哮喘儿童的T细胞亚群及其功能进行了研究。在哮喘儿童的新鲜外周血中发现，对茶碱敏感的T抑制细胞比例和功能降低。在外周血单个核细胞（PBMC）于无茶碱培养基中孵育后，接受茶碱治疗的哮喘儿童中对茶碱敏感的T细胞比例升高至正常水平。然而，它们对对照淋巴细胞增殖的抑制作用没有改变。
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