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水通道蛋白4阳性视神经脊髓炎谱系障碍中的短暂性肺间质病变

Transient Pulmonary Interstitial Lesions in Aquaporin-4-positive Neuromyelitis Optica Spectrum Disorder.

作者信息

Asato Yuko, Kamitani Toshiaki, Ootsuka Kuniyuki, Kuramochi Mizuki, Nakanishi Kozo, Shimada Tetsuya, Takahashi Toshiyuki, Misu Tatsuro, Aoki Masashi, Fujihara Kazuo, Kawabata Yoshinori

机构信息

Department of Internal Medicine, Tokyo Metropolitan Police Hospital, Japan.

Department of Internal Medicine, National Hospital Organization Saitama National Hospital, Japan.

出版信息

Intern Med. 2018 Oct 15;57(20):2981-2986. doi: 10.2169/internalmedicine.0580-17. Epub 2018 May 18.

DOI:10.2169/internalmedicine.0580-17
PMID:29780127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6232019/
Abstract

We herein report the case of a 76-year old man with aquaporin-4-Immunoglobulin-G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD), in whom transient interstitial pulmonary lesions developed at the early stage of the disease. Chest X-ray showed multiple infiltrative shadows in both upper lung fields, and computed tomography revealed abnormal shadows distributed randomly in the lungs. Surgical lung biopsy showed features of unclassifiable interstitial pneumonia, characterized by various types of air-space organization, which resulted in obscure lung structure. This is the first report to describe the pathological findings of interstitial pneumonia, which may represent a rare extra-central nervous system complication of NMOSD.

摘要

我们在此报告一例76岁男性水通道蛋白4-免疫球蛋白G（AQP4-IgG）阳性视神经脊髓炎谱系障碍（NMOSD）患者，其在疾病早期出现了短暂性间质性肺病变。胸部X线显示双上肺野有多个浸润阴影，计算机断层扫描显示肺部有随机分布的异常阴影。手术肺活检显示为无法分类的间质性肺炎特征，表现为各种类型的气腔结构，导致肺结构模糊。这是第一份描述间质性肺炎病理结果的报告，间质性肺炎可能是NMOSD一种罕见的中枢神经系统外并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/cd4cd9f51aaf/1349-7235-57-2981-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/08c78bf37a1e/1349-7235-57-2981-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/1ef690a3616d/1349-7235-57-2981-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/e736c1d635a2/1349-7235-57-2981-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/e079f6c657c6/1349-7235-57-2981-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/cd4cd9f51aaf/1349-7235-57-2981-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/08c78bf37a1e/1349-7235-57-2981-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/1ef690a3616d/1349-7235-57-2981-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/e736c1d635a2/1349-7235-57-2981-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/e079f6c657c6/1349-7235-57-2981-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b431/6232019/cd4cd9f51aaf/1349-7235-57-2981-g005.jpg

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本文引用的文献

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Multisystem involvement in neuromyelitis optica.视神经脊髓炎的多系统受累
Ann Indian Acad Neurol. 2015 Sep;18(Suppl 1):S56-8. doi: 10.4103/0972-2327.164830.
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The Clinical Characteristics of Primary Sjogren's Syndrome With Neuromyelitis Optica Spectrum Disorder in China: A STROBE-Compliant Article.中国原发性干燥综合征合并视神经脊髓炎谱系障碍的临床特征：一篇符合STROBE标准的文章。
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International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.
水通道蛋白在肺部健康和疾病中的作用：新兴角色、调节及临床意义。
Respir Med. 2020 Nov-Dec;174:106193. doi: 10.1016/j.rmed.2020.106193. Epub 2020 Oct 17.
视神经脊髓炎谱系障碍国际共识诊断标准
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